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Bhatt, Neeraj Kumar
- In Vivo Finding of Antiulcer Effect of Ethanolic Bark Extract of Delbergia sisso Roxb
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Authors
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1 VNS Institute of Pharmacy, Vidhya Vihar, Nathu Barkheda, Bhopal-462044, MP, IN
1 VNS Institute of Pharmacy, Vidhya Vihar, Nathu Barkheda, Bhopal-462044, MP, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 5 (2011), Pagination: 278-280Abstract
Delbergia sisso Roxb is a large deciduous tree found throughout India and is used mainly as aphrodisiac, abortifacient, expectorant, anthelmintic and antipyretic. The present study was conducted to assess the antiulcer activity of ethanolic extract of D. sisso Roxb in experimental animals. Ethanolic extract was prepared and administered orally after suspending in normal saline in experimental animals. Antiulcer activity was evaluated by pre treatment of ranitidine as well as in Aspirin Plus Pylorus Ligation test (Antisecretory method), the seperate results showed that the ethenolic extract potently and significantly reduced the score of ulcer, as compared to control animals. Oral administration of ethanolic extract significantly in Ethanol induced ulcer (Cytoprotective method), on the pretreatment of Ranitidine, the marked reduction in gastric lesion(shows significant ulcer inhibition). The cytoprotective action probably stimulate the prostaglandin synthesis, which in turn protect the gastric mucosa. In water immersion plus restraint method several hemorrhagic gastric glandular mucosal ulcers were observed in stress-induced control animals. Significant changes in the ulcer index compared with control by given Ranitidine and Dalbergia sisso Roxb. In conclusion, these results suggest the presence of antiulcer activity in ethenolic extract of bark of Dalbergia sisso Roxb.Keywords
Dalbergia sisso, Antiulcer, Ranitidine, Ethanolic Extract, Gastric Secretion.
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