Research Journal of Pharmacology and Pharmacodynamics

Ganesh G. Dhakad ¹, Sangita P. Shirsat ¹, Kaveri P. Tmabe ¹, Neha R. Jaiswal ¹

Affiliations
1 Ahinsa Institute of Pharmacy, Dondaicha 425408., IN

Abstract

Gene-based therapies for cancer in clinical trials include strategies that involve augmentation of immunotherapeutic and chemotherapeutic approaches. These strategies include ex vivo and in vivo cytokine gene transfer, drug sensitization with genes for prodrug delivery, and the use of drug-resistance genes for bone marrow protection from high-dose chemotherapy. Inactivation of oncogene expression and gene replacement for tumor suppressor genes are among the strategies for targeting the underlying genetic lesions in the cancer cell. A review of clinical trial results to date, primarily in patients with very advanced cancers refractory to conventional treatments, indicates that these treatments can mediate tumor regression with acceptably low toxicity. Vector development remains a critical area for future research. Important areas for future research include modifying viral vectors to reduce toxicity and immunogenicity, increasing the transduction efficiency of nonviral vectors, enhancing vector targeting and specificity, regulating gene expression, and identifying synergies between genebased agents and other cancer therapeutics.

Keywords

Gene Therapy on Cancer.

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Pratik C. Shirsath ¹, Sangita P. Shirsath ¹, Neha R. Jaiswal ¹

Affiliations
1 Ahinsa Institute of Pharmacy, Dondaicha, (4254018)., IN

Abstract

Piper betel Linn is commonly known as Betel leaf or pan is an important species of the Piperaceae family, is an evergreen and perennial creeper, with glossy heart-shaped leaves that are magnificent reservoirs of phenol compounds with ant proliferative, ant mutagenic, antibacterial and antioxidant properties. Piper betel Linn has been an important medicinal agent in the various traditional and folk systems of medicine in Southeast Asia countries. Piper betel leaves being largely consumed as a masticator and mouth freshener. It is valued as a mild stimulant and also has its use in Ayurvadic medicine. Phytochemicals studies show that Piper betle contains a wide variety of biologically active compounds whose concentration depends on the variety of the plant species. Many research studies on Piper betel has reported that it contains important chemical constituents such as Chavibetol, Chavibetol acetate, Caryophyllene, Allylpyrocatechol Diacetate, Camphene, Chavibetol methyl ether, Eugenol, a-Pinene, f- Pinene, u-Limonene, Saprobe, 1-8-cineol and Allylpyrocatechol mono acetate. These components are valuedas a stimulant for its medicinal properties like anti platelet, anti-inflammatory effects as well as immune modulator, gastro protective and antidiabetic activity. This review is focused on emphasizing the varied pharmacological properties of Piper betel Linn. And its future prospects for improved usage in treating numerous conditions. Current study focuses on evaluating antioxidant and antimicrobial potential of betel leaf. Antioxidant and antimicrobial potential study will help to build a database and promote the utilization of betel leaf as a medicinal herb.

Keywords

Piper betel Linn, antidepressant, traditional use, phytochemicals, pharmacological activity, Antibacterial activity, Antimicrobial activity, Antifungal activity, Antioxidant activity, Aqueous extract, Antidepressant, Chemical constituents, Medicinal properties.

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Ganesh G. Dhakad ¹, Kaveri P. Tambe ¹, Sangita P. Shirsat ¹, Neha R. Jaiswal ¹

Affiliations
1 Ahinsa Institute of Pharmacy, Dondaicha, 425408., IN

Abstract

Bottle gourd [Lagenaria siceraria (Molina) Standl.] is an important multi-purpose cucurbit crop grown for its leaf, fruit, and seed. It is widely cultivated and used for human consumption in sub-Saharan Africa (SSA) providing vital human nutrition and serving as food security crop. There is wide genetic variation among bottle gourd genetic resources in Africa for diverse qualitative and quantitative attributes for effective variety design, product development, and marketing. However, the crop is under- researched and -utilized, and improved varieties are yet to be developed and commercialized in the region. Therefore, the objective of this review is to provide the progress on bottle gourd genetic improvement and genetic analysis targeting agronomic and horticultural attributes, nutritional composition, biotic, and abiotic stress tolerance to guide current and future cultivar development, germplasm access, and conservation in SSA. The first section of the paper presents progress on breeding of bottle gourd for horticultural traits, agronomic performance, nutritional and antinutritional composition, and biotic and abiotic stress tolerance. This is followed by important highlights on key genetic resources of cultivated and wild bottle gourd for demand driven breeding. Lastly, the review summaries advance in bottle gourd genomics, genetic engineering and genome editing. Information presented in this paper should aid bottle gourd breeders and agronomists to develop and deploy new generation and promising varieties with farmer- and market -preferred attributes.

Keywords

Bottle Gourd, Human Health.

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Ganesh G. Dhakad ¹, Kaveri P. Tambe ¹, Sangita P. Shirsat ¹, Neha R. Jaiswal ¹

Affiliations
1 Ahinsa Institute of Pharmacy, Dondaicha, 425408., IN

Abstract

Nyctanthes arbortristis is one of the most useful traditional medicinal plants in India. It is distributed widely in sub-Himalayan regions and Southwards to Godavari. Each part of the plant has some important medicinal value and is thus commercially exploitable1 . It is now considered as a valuable source of several unique products for the medicines against various diseases and also for the development of some industrial products. The present review is to focus on the potential phyto-chemicals and pharmacological activity of plant N. Arbortristis1 . Various parts of the plant like seeds, leaves, flowers, bark and fruits have been investigated for their significant pharmacological activity. Phyto-chemicals like flavanoid, glycoside, oleanic acid, essential oils, tannic acid, carotene, friedeline, lupeol, glucose, benzoic acid have been reported for significant hair tonic, hepatoprotective, anti-leishmaniasis, anti-viral, antifungal, anti-pyretic, anti-histaminic, anti-malerial, anti-bacterial, antiinflammatory and anti-oxidant activities of Night jasmine and emphasizes the need for further exploring available information

Keywords

Medicinal use, Nyctanthes arbortristis

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Dhiraj S. Girase ¹, Rahulsing G. Girase ¹, Prasad P. Girase ¹, Neha R. Jaiswal ¹

Affiliations
1 Department of Microbiology, Ahinsa Institute of Pharmacy, Dhule Road, Dondaicha, 425408, IN

Abstract

The development of microbiology began in the 19th century with the invention of the culture medium. Bacterial culture was the first method to study human microbiota in 1860. Louis pasteur was the first to propagate bacteria on culture media. The culture media provides the essential nutrients such as carbohydrates, protein, vitamins and some growth factors for the proper development of bacteria. Nowadays, these growth medias are prepared by different expensive chemical ingredients in laboratories for research experiments, which ultimately makes our experiments expensive. Instead of using high-cost culture media, fruit waste material could prove to be a good alternate source for the production of low-cost media. The waste generated in household practices and kitchen includes vegetables and fruit waste. It is waste that almost every house generates every day. It can serve as a good source of nutrients and vitamins for in microorganisms. Hence these materials can be used to formulate solid media for the growth of bacteria. In the current study waste material like mango peels, banana peels, lemon peels and ground nut shell have been included to formulate the media. This material was collected from kitchen waste and vegetable market. Comparing the growth of organism (lactobacillus bulgaricus) standard commercial media and fruit waste with agar, it was found that the media prepared from fruit waste serves as a good and inexpensive source of nutrients for many bacteria. Thus, it can good be feather and used commercially for isolation and cultivation of various microorganisms.

Keywords

Culture media, Bacteria, Fruit waste, Nutrients, Lactobacillus bulgaricus.

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