Research Journal of Pharmacology and Pharmacodynamics

T. Prabhakar ¹, P. K. M. Nagarathna ¹, B. S. Vikram ¹

Affiliations
1 Karnataka College of Pharmacy, No.33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post Bangalore-64, IN

Abstract

The aim of the present study was to screen the antidiabetic potential of the ischolar_main of Sida cordifolia linn. In the present study, ischolar_main of Sida cordifolia linn was screened for antidiabetic activity. Root powder of Sida cordifolia was subjected to hot continuous extraction (soxhlet) with various solvents like petroleum ether, (40-600° C), chloroform, butanol, butanone and alcohol. Aqueous extract was prepared by cold maceration. After preliminary phytochemical investigation, all the extracts were evaluated for anti diabetic activity after single dose (acute study) and after prolonged treatment (chronic study in alloxan induced diabetic albino rats. Al thel extracts were given orally at a dose of 250mg/Kg b.w. Glibenclamide was used as standard drug (10mg/Kg b.w. P.o). Alcohol butonal, Chloroform, aqueous and butanone showed significant antidiabetic activity in acute as well as prolonged treatment compared to control. Petrolium ether extract did not show significant anti diabetic activity on prolonged treatment. Among all the extracts, alcoholic extracts had more significantly reduced the blood glucose level after single dose and nearly equal to standard glibenclamide after prolonged treatment.

Keywords

Sida cordifolia, Anti Diabetic, Glibenclamide, Alloxan.

Full Text