Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Bhoja Raju, P.
- Evaluation of Cardiotonic Activity of some Traditionally Used Medicinal Plants
Abstract Views :408 |
PDF Views:2
Authors
K. Sanjeev Kumar
1,
V. Vijay Kumar
1,
A. G. Prasanthi
1,
L. K. Kanthal
1,
P. Bhoja Raju
1,
K. Satyavathi
1
Affiliations
1 Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, IN
1 Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 2 (2013), Pagination: 87-91Abstract
The present study was undertaken to evaluate the cardiotonic activity of the aqueous, methanolic and chloroform extracts of the ischolar_mains of Hemidesmus indicus and fruits of Terminalia bellirica, Terminalia chebula. The cardiotonic effect of aqueous, methanolic and chloroform extracts of the three plants was studied by using isolated frog heart perfusion technique (IFHP). Ringer solution without calcium was used as a vehicle for administration of aqueous, methanolic and chloroform extracts as test and digoxin as standard. A significant increase in the height of force of contraction (positive ionotropic effect) and decrease in heart rate (negative chronotropic effect) was observed and as compared to standard, test drug showed wide therapeutic index.Keywords
Cardiotinic Activity, Frog Heart Perfusion Technique, Digoxin, Therapeutic Index,Hemidesmus Indicus, Terminalia Bellirica, Terminalia Chebula
References
- Tripathi KD. Cardiac glycosides and drugs for CCF, Essentials of medical pharmacology. 5 th ed. Medical Publishers; 2003, 457-467.
- Barar FSK, Essentials of Pharmacotherapeutics, 1st edition, S.Chand Publications, 1985, 253-254
- Satoskar RS, Bhandarkar SD, Rege NN. Handbook of pharmacology and pharmacotherapeutics. 16 th ed. Popular Prakashan; 1997, 352-355.
- Arun, V; Liju, V; Reena, J; et al. 2007. Traditional Remedies of Kani Tribes of Kottoor Reserve Forest, Agasthyavanam, Thiruvananthapuram, Kerala. Indian Journal of Traditional Knowledge, 2007, Vol.6(4), 589-594.
- Alam MI, Audpy B, Gomes A. Viper venom neutralization by Indian medicinal plants (Hemidesmus indicus and Pluchea indica). Phytothery Resonance, 1996; 10: 58-61.
- Alam Badrul . Antioxidant,Antimicrobial and Toxicity studies of the Different Fractions of Fruits of Terminalia belerica Roxb. Global Journal of Pharmacology. 2011;5(1):07-17.
- Kumudhavalli MV, Vyas Mohit and Jayakar B. Phytochemical and Pharmacological evalution of the plant fruit of Terminalia belerica Roxb, International Journal of Pharmacy and Life Sciences. 2010; 1(1):1-11.
- Suguna L, Singh S, Sivakumar P, Sampath P, Chandrakasan G. Influence of Terminalia chebula on dermal wound healing in rats. Phyther Res. 2002; 16:227–231.
- Dama G.Y.,Tare H.L.,Gore M.S.,Shende V.S.,Deore S.R., Khandagale S.T.,Kandekar A.E. Comparative Cardiotonic Activity Of Helicteres Isora With Digoxin On Isolated Frog Heart. International Journal of Preclinical Research,Vol 2 | Issue 2 | Jul –Dec 2011 |81-86.
- Mohire N.C., Salunkhe V.R., Bhaise S.B., Yadev A.V. Cardiotonic activity of aqueous extract of heartwood of Pterocarpus marsupium. Indian Journal of Experimental Biology, Vol.45, June 2007, 532-537.
- Kulkarni SK, Handbook of Experimental Pharmacology, 2nd Edition, Vallabh Prakashan, 9, 1993, 74-76.
- Kale SR, Kale RR. Practical Pharmacology and toxicology, 6th edition, Nirali Prakashan, 2003, 27- 28.
- Tare HL, Thube BB. Comparative cardiotonic activity of C.angustifolia with digoxin on perfused frog heart. IJPRD, 1(1), 2009, 1-14.
- Rai P.T. et al., Evaluation of Cardiotonic activity of leaves of Vitex negundo linn, International Journal of Green Pharmacy, Oct.-Dec.-2009, 306-309.
- Goyal Ramesh K., Practicals in Pharmacology, 6th edition, B.S.Shah Prakashan, 2006-2007, 107-108.
- Patel Rashmika P., Patel Manish P. Cardiotonic activity of isolated cardiac glycoside from the fruits of Corchorus aestuans linn, International Research Journal of Pharmacy, 2012, 3(7), 239-242.
- Evaluation of antimicrobial and anthelmintic activities of the aerial parts of Elephantopus scaber L.
Abstract Views :336 |
PDF Views:2
Authors
Lakshmi Kanta Kanthal
1,
B. V. V. S. Surya Kiran
1,
K. Satyavathi
1,
P. Bhoja Raju
1,
Subhas Sahoo
2
Affiliations
1 Koringa College of Pharmacy, Korangi, Tallarevu [M], E. G. Dist. - 533 461, A.P, IN
2 Pulla Reddy Institute of Pharmacy, Annaram, Jinnaram (M), Medak Dist., A.P., IN
1 Koringa College of Pharmacy, Korangi, Tallarevu [M], E. G. Dist. - 533 461, A.P, IN
2 Pulla Reddy Institute of Pharmacy, Annaram, Jinnaram (M), Medak Dist., A.P., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 3 (2013), Pagination: 193-196Abstract
Herbal medicine is having very old history. Plants are the typical manufacturers of complex drug molecules, which serve as a prototype to develop more effective and less toxic medicines. The antimicrobial activities of medicinal plants can be attributed to the secondary metabolites such as alkaloids, flavonoids, tannins, terpenoids that are present in these plants. Helminthes infections are becoming a cause to disorders like eosinophilia, pneumonia, anaemia, and under nourishment. Anti-helmethic drugs will expel these worms by paralyzing or by killing the worms. In traditional system of medicine a large number of plants are claimed to have anthelmintic activity. Chemical study started from 1960's and showed that constituents of E. scaber L. include flavonoids, triterpenoids, flavonoid esters and sesquiterpene lactones. Elephantopus scaber L. belongs to the family Asteraceae. The present study was carried out to screen the antimicrobial and anthelmintic activities of Elephantopus scaber L. The activities of extracts of the plant material are compared with the piperazine citrate. The n-hexane, chloroform and methanolic extracts shows concentration dependent and significant anthelmintic activity compared to the piperazine citrate and Albendazole and Amoxicillin and Fluconazole for the case of antimicrobial activity. Thus the anthelmintic and antimicrobial activities of Elephantopus scaber L. are demonstrated for the first time.Keywords
Elephantopus scaber L, Antimicrobial Activities, Antihelmethic Drugs, Pheritima posthumaReferences
- Thomson, W.A.R., 1978. Medicines from the Earth. Maidenhead, United Kingdom. McGraw-Hill Book Co.
- Stockwell, C., 1988. Nature’s pharmacy. London, United Kingdom. Century Hutchinson Ltd.
- Gerhartz, W., Y.S. Yamamota, F.T. Campbell, R. Pfefferkorn and J.F. Rounsaville, 1985. Ullmann’s Encyclopedia of Industrial.
- Srivastava, J., J. Lambert and N. Vietmeyer, 1996.. Medicinal plants: An expanding role in development. World Bank Technical Paper. No. 320.
- Uniyal, S.K., K.N. Singh, P. Jamwal and B. Lal, 2006. Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western Himalayan. J. Ethnobiol. Ethnomed, 2: 1-14.
- Reddy PS, Jamil K and Madhusudhan P. Antibacterial activity of isolates from Piper longum and Taxus baccata. Pharma. Biol. 39, 236-238 (2001).
- Ateb DA and ErdoUrul OT Antimicrobial activities of various medicinal and commercial plant extracts. Turk. J. Biol. 27, 157- 162 (2003).
- Sher A; Antimicrobial activity of natural products from medicinal plants. Gomal J Med Sci.; 7(1):72-78 (2009)
- Thorn G.M, Harrison‘s Principles of internal Medicine, 1977, Mc Grew Hill, New York
- AA Kale et al; JP Salvekara. J. Chem. Pharm. Res., 2011, 3(2), 298-302.
- Y Shivhare et al J. Chem. Pharm. Res., 2011, 3(1), 488-491.
- Lee K H, Cowherd C M and Wolo M T. Antitumor agents. XV: deoxyelephantopin, an antitumor principle from Elephantopus carolinianus Willd. J Pharm Sci 1975, 64, 1572–3.
- Fuchino H, Koide T, Takahashi M, Sekita S and Satake M. New sesquiterpene lactones from Elephantopus mollis and their leishmanicidal activities. Plant Med 2001, 67, 647–53
- Rajkapoor B, Jayakar B and Anandan R. Antitumor activity of Elephantos scaber Linn. Against Dalton’s Ascitic Lymphoma. Indian J Pharm Sci., 2002, 64, 71 – 73