Research Journal of Pharmacology and Pharmacodynamics

T. Raja Sekharan ¹, M. Syam Mohan ², P. Natarajan ³, A. S. William ³, Arputha Sundar ³, A. Thanga Thirupathi ³, R. Venkatnarayanan ⁴

Affiliations
1 Department of Pharmaceutics , Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam – 626 130, Sivakasi, Tamil Nadu, IN
2 UPM Makna Cancer Research Lab, Serdang - 43400, Selangor, MY
3 Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam – 626 130, Sivakasi, Tamil Nadu, IN
4 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641 402, Tamil Nadu, IN

Abstract

Petroleum ether, Chloroform, Ethanol and Aqueous extracts of Jasminum grandiflorum Linn leaves were tested for wound healing and antibacterial activity. Investigation were undertaken to screen the wound healing activity of different extracts of the leaves of Jasminum grandiflorum Linn on excision wound models in albino rats. The aqueous extracts shows significance wound healing activity when compared to the standard (Povidone iodine ointments). Other extract also shows wound healing activity but the wound contraction was less when compared to aqueous extracts and standard. For Salmonella typhi the zone of inhibition for petroleum ether extract is equal and for chloroform extract it is more active compared to that of the standard (Ciprofloxacin disc 5mcg/disc). Ethanolic extract is more active against Staphylococcus aureus than other microorganisms. Aqueous extract is more effective against Streptococcus pyogen and less active against Proteus when compared to the standard.

Keywords

Jasminum Grandiflorum Linn; Antibacterial Activity, Wound Healing Activity.

Full Text

     

P. Natarajan ¹, A. Thanga Thirupathi ², T. Raja Sekharan ², A. S. William Arputha Sundar ², R. Arivukkarasu ², M. Ganesan ²

Affiliations
1 Department of Pharmacology, Sankaralingam Bhuvaneswari College of Pharmacy, 3/77-C, Anaikuttam Road, Anaikuttam, Sivakasi-626 130, Tamil Nadu, IN
2 Department of Pharmacology, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi, Tamil Nadu, IN

Abstract

Hepatoprotective effect of a methanolic extract of Glinus oppositifolius Linn ischolar_main on liver damage induced by Carbon tetrachloride (CCl₄) in albino rats. Oral administration of the methanolic extract showed significant protective action made evident by its effect on the level of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), total bilirubin and direct bilirubin. The results of this study showed that treatment with Glinus oppositifolius Linn extracts appears to enhance the recovery from hepatic damage induced by CCl₄.

Keywords

Glinus oppositifolius Linn, Hepatoprotective, Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Total Bilirubin and Direct Bilirubin.

Full Text

     

P. Natarajan ¹, A. Thanga Thirupati ¹, R. Sutharsingh ², J. Immanuvel Manicaraj ¹, N. Vijayakrishnan ¹

Affiliations
1 Department of Pharmacology, Sankaralingham Bhuvaneswari College of Pharmacy, Anaikuttam, Sivakasi-626130, IN
2 Department of Phamacognosy, Sankaralingham Bhuvaneswari College of Pharmacy, Anaikuttam, Sivakasi-626130, IN

Abstract

The anti inflammatory effects of Methanolic extract of Ctenolepis garcinii (burm. f) was assessed by carrageenan induced rat paw edema at the doses of 100 and 200 mg/kg p.o. The Methanolic extract 200 mg/kg p.o. shows significant and maximum activity, whose potency is less than the standard Diclofenac sodium. At the same dose, the analgesic activity was also assessed by Tail immersion method, The Methanolic extract of 200 mg/kg p.o. shows increased in the time of tail withdrawal response, which activity is significant as compared to the Standard Diclofenac sodium.

Keywords

Ctenolepis garcinii (burm.f), Analgesic, Anti Inflammatory, Methanolic Extract, Diclofenac Sodium.

Full Text