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Uppala, Praveen Kumar
- Evaluation of Anti-depressant Activity of Methanolic Seed Extract of Avena Sativa L. in Mice
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Authors
Affiliations
1 K.V.K College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
2 T.R.R College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
3 College of Pharmaceutical Sciences, Affiliated to Biju Patnaik University of Technology, Rourkela, IN
1 K.V.K College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
2 T.R.R College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
3 College of Pharmaceutical Sciences, Affiliated to Biju Patnaik University of Technology, Rourkela, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 4 (2013), Pagination: 212-217Abstract
The main objective of the study to evaluate the Anti-depressant activity of seeds extract of Avena sativa in Forced swim test (FST), Tail Suspension test (TST) and antagonism of Apomorphine induced hypothermia in mice. Phytochemical screening showed presence of carbohydrates, alkaloids, flavanoids, steroids, glycosides, saponins, amino acids, gums and mucilage. MSEAS did not produce any lethal effect even upto 2000mg/kg, p.o during Acute Oral Toxicity study. In FST and TST, MSEAS showed diminution of duration of immobility time in 100mg/kg but not in 200mg/kg. In antagonism of Apomorphine induced hypothermia model, Desipramine but not both doses of MSEAS significantly antagonised the Apomorphine induced hypothermia. From the above finding concluding that, shortening of immobility time in the FST and TST indicating, MSEAS showed antidepressant activity acting either by the enhancement of central 5-HT or catecholamine neurotransmission and Antagonism of Apomorphine induced Hypothermia indicating, MSEAS was not acting through Adrenergic system.Keywords
avena Sativa, Antidepressant Activity, Forced Swim Test, Tail Suspension Test, Antagonising Apomorphine Induced Hypothermia
References
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- Evaluation of Anthelmintic Activity of the Chloroform and Aqueous Extracts of Leaves of Couroupita guianensis on Pheretima posthuma by Worm Motility Assay Method
Abstract Views :224 |
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Authors
Affiliations
1 Bhaskara Institute of Pharmacy, Bobbili, Vizianagaram District, IN
1 Bhaskara Institute of Pharmacy, Bobbili, Vizianagaram District, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 8, No 3 (2016), Pagination: 118-122Abstract
Objective: To investigate Anthelmintic Activity of the Chloroform and Aqueous Extracts of leaves of Couroupita guianensis on Pheretima posthuma by Worm Motility Assay Method
Methods: The Anthelmintic activity of the Aqueous and Chloroform Extracts of Leaves of Couroupita guianensis on Pheretima posthuma by Worm Motility Assay Method and the results were compared for the both extracts. Anthelmintic activity is compared with standard drug Albendazole.
Results: The chloroform extract showed better anthelmintic activity at a concentration of 200 mg/ml, whereas the aqueous extract also showed paralysis and death at similar concentrations against Indian earth worms. The other test concentrations of both the extracts showed marked degree of anthelmintic activity. The anthelmintic effect of extracts is comparable with that of the effect produced by the standard drug albendazole.
Conclusion: From the above finding concluding that, the plant possesses significant anthelmintic activity at 200 mg/ml concentration measured by time taken for paralyse / death of the earth worms. The current investigation leads to conclusion that the leaves of Couroupita guianensis have potent anthelmintic activity when compared with the conventionally used drug