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Adeshara, Subodh
- Evaluation of Antidepressant Activity of Ailanthus excelsa roxb. Using Mice as Experimental Animal
Authors
1 Department of Pharmacology and Toxicology Dharmsinh Desai University, College Road, Nadiad- 387001., IN
2 Dharmsinh Desai University, College Road, Nadiad- 387001, IN
3 Shree Swaminarayan College of Pharmacy, Village- Saij, NH-8, Kalol- 382721., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 3 (2011), Pagination: 102-104Abstract
Introduction: Ailanthus excelsa Roxb. is a tree belonging to family Simaroubaceae, commonly known as a plant of Heaven. The bark of the plant is reported for various pharmacological activities including ear ache, aantimicrobial, anti-viral, antitumor, cytotoxic, hypotensive, abortifacient, diabetes mellitus, obesity and various uterine disorders in Ayurveda. Methanolic extract of Ailanthus excelsa (MeAe) in 150 mg/kg and 100 mg/kg doses are used for evaluation of antidepressant activity.
Objective: To evaluate antidepressant activity of Ailanthus excelsa Roxb. using mice as experimental animal by actophotometer and forced swim induced despair behaviour methods.
Methods: Swiss albino mice were randomly allocated to 4 groups (n=6); Group I (Normal Control), Group II (Standard group), group III and Group IV (Test Groups). Group I received distilled water while Group II, III and Group IV received Fluoxetine (10 mg/kg, i.p), MeAe 100 mg/kg and 150 mg/kg per oral respectively. Stem bark was extracted by cold maceration process. Antidepressant activity was estimated by actophotometer and forced swim induced despair behaviour methods.
Results: MeAe at dose of 150 mg/kg showed highly significant (p<0.01) increase in locomotion and decrease in immobility period while MeAe 100 mg/kg showed significant results in both methods.
Conclusion: MeAe (150 mg/kg and 100 mg/kg) has antidepressant activity in mice.
Keywords
Ailanthus excelsa Roxb., Antidepressant Activity, Actophotometer, Forced Swim Behaviour And MeAe.
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