Mechanistic Aspects:Biosynthesis of Silver Nanoparticles from Proteus mirabilis and its Antimicrobial Study

Disease causing microbes that have become resistant to drug therapy are an increasing public health problem. Therefore there is an urgent need to develop new bactericides. The present study deals with synthesis of silver nanoparticles were prepared from Proteus mirabilis and their shape and size distribution characterized by particle analyzer and scanning electron microscopic study (SEM). Ultraviolet-Visible (UV-VIS) spectrum of the aqueous media obtained from the Proteus mirabilis containing silver ion showed a peak around 420nm corresponding to the plasmon absorbance of silver nanoparticles. Invitro studies indicated that the formed silver nanoparticles showed variable antimicrobial activity against Staphylococcus aureus, Pseudomonas species, Proteus vulgaris and Bacillus subtilis. These results suggest that silver nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.