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Screening of Antipyretic and Analgesic Potential of Ethanol Extract of Cassytha filiformis Leaves


Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur (C.G.)-493111, India
2 Oriental College of Pharmacy, Raisen Road, Bhopal-462021 (M.P.),, India
3 Shridhar University, Pilani-333031 (Rajasthan), India
4 Institute of Pharmacy, Kathog-177101 (H.P.), India
     

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The present study was undertaken to evaluate the antipyretic and analgesic activities of the alcohol extract of Cassytha filiformis leaves. The antipyretic activity of C. filiformis (25mg/kg, 50mg/kg and 100mg/kg) was studied in Brewer’s yeast induced pyrexia in rats. The analgesic activity of C. filiformis (25mg/kg, 50mg/kg and 100mg/kg) was studied using Eddy’s hot plate method and heat conduction method in mice. The extract showed significant reduction in the elevated body temperature of rat which was compared with standard Paracetamol. The extract produced significant increase in the reaction time by Eddy”s hot plate method and tail flick method in mice which was compared with standard diclofenac sodium. The alcohol extract of leaves of C. filiformis may have antipyretic and analgesic activities.

Keywords

Cassytha filiformis, Antipyretic, Pyrexia, Analgesic, Paracetamo.
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  • Screening of Antipyretic and Analgesic Potential of Ethanol Extract of Cassytha filiformis Leaves

Abstract Views: 210  |  PDF Views: 1

Authors

Ram Kumar Sahu
Columbia Institute of Pharmacy, Tekari, Raipur (C.G.)-493111, India
Amit Roy
Columbia Institute of Pharmacy, Tekari, Raipur (C.G.)-493111, India
Saurabh Kothiya
Oriental College of Pharmacy, Raisen Road, Bhopal-462021 (M.P.),, India
Anup Kumar Maurya
Shridhar University, Pilani-333031 (Rajasthan), India
Rajesh Kumar
Institute of Pharmacy, Kathog-177101 (H.P.), India

Abstract


The present study was undertaken to evaluate the antipyretic and analgesic activities of the alcohol extract of Cassytha filiformis leaves. The antipyretic activity of C. filiformis (25mg/kg, 50mg/kg and 100mg/kg) was studied in Brewer’s yeast induced pyrexia in rats. The analgesic activity of C. filiformis (25mg/kg, 50mg/kg and 100mg/kg) was studied using Eddy’s hot plate method and heat conduction method in mice. The extract showed significant reduction in the elevated body temperature of rat which was compared with standard Paracetamol. The extract produced significant increase in the reaction time by Eddy”s hot plate method and tail flick method in mice which was compared with standard diclofenac sodium. The alcohol extract of leaves of C. filiformis may have antipyretic and analgesic activities.

Keywords


Cassytha filiformis, Antipyretic, Pyrexia, Analgesic, Paracetamo.