Antimutagenic Effects of Tribulus terristris Fruit Extract on Micronucleus

In this study, the protective effect of hydromethanolic fruit extract of Tribulus terristris is reported against Cyclophosphamide (CP) induced micronuclei (MN) formation in bone marrow cells of mice. Swiss albino mice were treated with a single i.p. dose of 500, 1000 and 1500 mg/kg b.w. with Tribulus terristris fruit extract prior to CP administration. A significant inhibition was noticed in the micronuclei frequencies, as it gradually decreased with increase in concentration of the extract suggesting a protective effect and the extract alone had not induced MN formation, reiterating the fact that the extract has no pro-mutagenic components.