An Overview on Diabetes Mellitus with Emphasis on Non Invasive Techniques of Insulin Delivery

India has largest number of people suffering from diabetes mellitus in the world. Diabetes mellitus is a progressive disease characterized by both insulin resistance and cell failure, resulting in a decline in insulin secretion and increased blood glucose levels. During the past three decades, various approaches have been studied for delivery of insulin. To eliminate the needle from insulin delivery and to replace it with non-invasive alternative routes has driven rigorous pharmaceutical research to replace the injectable forms of insulin. Recently, various approaches have been studied involving many strategies using various technologies that have shown success in delivering insulin, which are designed to overcome the inherent barriers for insulin uptake across the gastrointestinal tract, mucosal membranes and skin. New approaches to diabetes mellitus herapy have been shown to improve survival and well being of patients with disease. With increasing translational research and a better understanding of the molecular basis of diabetes mellitus, a number of targets have been identified in various preclinical studies. In this review diabetes mellitus, type, strategies with special emphasis on advancement in treatment of diabetes mellitusby non invensive therapies has been discussed in detail.