Research Journal of Science and Technology

Shashikant R. Pattan ¹, Nachiket S. Dighe ², Deepak S. Musmade ¹, Manisha S. Kedar ¹, Smita K. Parjane ¹, Priyanka P. Gadhave ¹, Manjusha S. Sanap ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, A/PLoni Bk., Taluka -Rahata, Dist-Ahmednagar 413736, IN

Abstract

The present review article on tools for synthesis of natural products is to significantly facilitate organic synthesis of natural products which are of significant biological importance by the implementation of new concepts for catalysis. We focus on the recent development in natural product synthesis with the help of newer methods of organic synthesis.

Keywords

Natural Products, Methods of Synthesis, Combinatorial Chemistry.

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Nachiket S. Dighe ¹, Shashikant R. Pattan ², Deepak S. Musmade ², Abhijeet N. Merekar ³, Manisha S. Kedar ², Deepak K. Thakur ², Pratik V. Patel ²

Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, A/PLoni Bk., Taluka -Rahata, Dist-Ahmednagar 413736, IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
3 Department of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN

Abstract

Many natural products from marine sources are endowed with promising anti cancer activity, thus representing invaluable leads in the plans for drug discovery. In this context, organic synthesis plays a decisive role in confirming (or revising) the chemical structures of the natural compounds allowing also access to suitable amounts of the target (and its analogs) for structure activity relationship (SAR) investigations. In this overview, we focus on the total and partial synthesis of anti cancer marine metabolites and their related compounds discussing the retro synthetic analysis of the strategies adopted.

Keywords

Marine, Anti Cancer Activity, Synthesis of Dictyostatin.

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Shashikant R. Pattan ¹, Nachiket S. Dighe ², H. V. Shinde ¹, Deepak S. Musmade ¹, Mangesh B. Hole ¹, Vinayak M. Gaware ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar A/P- Loni Bk. Taluka -Rahata, Dist-Ahmednagar 413736, IN

Abstract

The present review article on Umpolung chemistry is to significantly facilitate organic synthesis by the implementation of new concepts for catalysis. We focus on the recent development of N- heterocyclic carbenes mediated organic reaction and its implementation to the synthesis of heterocycles of biological importance.

Keywords

Umpolung, N-Heterocyclic Carbenes, Organomettalic Catalyst.

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