Research Journal of Science and Technology

Sachin R. Patil ¹, Swati Patil ², Ravi Kumar ¹, M. B. Patil ³, Mahesh S. Paschapur ⁴

Affiliations
1 Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN

Abstract

The present study deals with the formulation and characterization of cross linked chitosan/ albumin microspheres containing an NSAID drug Aceclofenac. The microspheres were prepared by suspension cross linking method using gluteraldehyde as a cross linking agent of the polymer matrix. Total eight formulation batches (F1 to F8) were formulated using chitosan/albumin alone and in combinations. The formulations were subjected to various evaluation parameters like % practical yield, entrapment efficiency, particle size distribution, swelling ratio, In vitro release and stability studies. Perfectly spherical cross linked microspheres loaded with aceclofenac were obtained in the size range of 50 - 500 μm. The % practical yield, entrapment efficiency, particle size, swelling ratio were increased with increased concentration of polymer used. The release of aceclofenac was influenced by polymer concentration and size of microspheres. The stability studies of formulation showed 4°C is suitable temperature for storage.

Keywords

Cross Linked Microspheres, Controlled Release, Chitosan, Albumin, Aceclofenac.

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Ravi Kumar ¹, Swati Patil ², M. B. Patil ³, Mahesh S. Paschapur ⁴, Sachin R. Patil ¹

Affiliations
1 Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN

Abstract

Fast dissolving tablets of Captopril were prepared by Wow tab and Effervescent technologies. In this study our aim was to provide the tablet that quickly disintegrates or dissolves upon contact with saliva and also to provide a good mouth feel. The excipients used in both the technologies not only aid fast disintegration of tablets, but also mask the slight bitter taste of drug. All the prepared formulations were evaluated for thickness, hardness, friability, weight variation, drug content, and disintegration time and drug dissolution. Tablets from Wow tab and Effervescent technologies have shown 94 and 96% of the drug release at the end of 10 min respectively. Study has shown that 8:6 ratio of sodium bicarbonate and citric acid in the Captopril fast dissolving tablets gave good soothing and excellent mouth feel. Tablet prepared by Wow tab technology, formulation W5 and W6 using low moldability saccharide (lactose and mannitol) showed rapid disintegration and released about 92 and 96% drug respectively. Study concluded that fast dissolving tablets of Captopril could be prepared successfully by above mentioned methods. Tablets imparted patient benefits and increased consumer satisfaction, despite the different mechanisms involved in these techniques.

Keywords

Fast-Dissolving Tablets, Captopril, ACE Inhibitor, Oral Cavity, In vitro Dissolution.

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