Research Journal of Topical and Cosmetic Sciences

Jemima Daniela Shultz ¹, Amanda C Caritá ¹, Hana Mohd ², Bozena Michniak-Kohn ², Laura Moretti Aiello ³, Gislaine Ricci Leonardi ³

Affiliations
1 Medicine Department, Graduate Program in Translational Medicine, Federal University of Sao Paulo, Rua Pedro de Toledo, 720 - 2º Floor, Zip Code: 01039032, São Paulo (SP), BR
2 Center for Dermal Research, The State University of New Jersey – Rutgers, 145 Bevier Rd, Piscataway, NJ 08854, US
3 Faculty of Pharmaceutical Science, University of Campinas - Unicamp, Rua Cândido Portinari, 200, Zip Code: 13083-859, Campinas (SP), BR

Abstract

Vitamin C (ascorbic acid) is widely used in skin care products, yet it is a challenging compound due to its physical and chemical instability. Severalstrategies have been applied to improve the stability of vitamin C, such as the addition of other antioxidants in the system (e.g., Vitamin E, ferulic acid, and sodium metabisulfite). In addition, clay minerals have been used in cosmetic preparations due to their high ion-exchange capacity, thermal stability, softness, the small size of their particles, and their attractive adsorptive properties. In this study, we proposed the association of kaolin clay and well-known antioxidants and chelators to improve the stability of vitamin C. Although the kaolin clay alone did not improve the stability of the vitamin C, the clay mineral in association with certain chelators and/or antioxidants could improve the stability of formulations containing vitamin C.

Keywords

Ascorbic acid, Clay minerals, Chemical stability, HPLC

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