![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
In-vitro Antiurolithiatic Activity of Strychnos potatorum L.F.
With the passage of time, many problems associated with frequent use of synthetic drugs become prominent, like severe side effects and resistance of microbes against these drugs. On the other side, these drugs are expensive and a large population cannot afford these drugs. In recent times, research on medicinal plants has been intensified all over the world. Kidney stone formation (Urolithiasis) is a complex process that includes many chemical events such as super saturation, nucleation, growth, aggregation and retention of urinary stone constituents within the renal tubules. The currently employed medical management of urinary calculi includes lithotripsy and surgical procedures are expensive and complete recurrence is rare. In this respect, it was noted that there was little attempts reported on in vitro crystallization, growth and dissolution studies of Strychnos potatorum L.f. Strychnos potatorum L.f. is a dry deciduous tree and coming under the family Loganiaceae. Mainly four parts of the plant were taken for the study, leaf, stem, bark and seed. The four parts were extracted with petroleum ether, chloroform, methanol and water in the increasing order of polarity. The treatment of urolithiasis is mainly considered with the dissolution of existing stones and preventing recurrence of stones. The per cent inhibition of turbidity increased with concentration of extract and methanol extract of seed showed maximum dissolution of calcium oxalate stones in vitro.
Keywords
Urolithiasis, Loganiaceae, Lithotripsy, Strychnos potatorum L.f.
User
Font Size
Information
- Atmani F, Khan S.R. (2000). Effects of an extract from Herniaria hirsuta on calcium oxalate crystallization in vitro. British Journal of Urology International, 85, 621-625.
- Atmania F, Slimania Y, Mimounib M, Aziz B, Hachtb B, Ziyyata A.(2004). Effect of aqueous extract from Herniaria hirsuta L. on experimentally nephrolithiatic rats. Journal of Ethanopharmacology, 95, 87-93.
- Barros ME, Schor N, Boim MA.(2003). Effects of an aqueous extract from Phyllantus niruri on calcium oxalate crystallization in vitro. Uroogical Research, 30, 374-379.
- Chauhan CK, Joshy MJ, Vaidya ADB. Growth inhibition of struvite crystals by the aqueous ischolar_main extract of Rotula aquatica. Indian Journal of Biochemistry and Biophysics, 48, 202-207.
- Farroq SM. (2004). Preventive role in phycocyamin: A study of oxalate medicated renal cell injury. Chemico- Bioogical Interactions, 149, 1-7.
- Hassan RBA. (2012).Medicinal Plants (Importance and Uses). Pharmaceutica Analytica Acta, 3,139.
- Hennequin C, Lalanne V, Daudon M, Lacour B, Drueke T. (1993). A new approach to studying inhibitors of calcium oxalate crystal growth. Urological Research, 21 ,101-108.
- Ibrahim AI, Shelty SD, Awad RM, Patel KP. (1991).Prognosticfactors in the conservative treatment of ureteric stones. Brazilian Journal of Urology, 67, 358–361.
- Masao T, Osamu M, Kazuhiro Y, Ken-Ichi KT, Shiro T, Akihiko O. (2000). Fibronectin as a potent inhibitors of calcium oxalate urolithiasis. Journal of Urology, 164, 1718-1723.
- Miller NL, Lingeman LE. (2007). Management of kidney stones. British Medical Journal, 334, 468-472.
- Phatak SR, Hendre AS. (2015). In-vitro antiurolithiatic activity of Kalanchoe pinnata extract. International Journal of Pharmacognosy and Phytochemical Research, 7, 275-279.
- Radha SR.(2015). Extraction, isolation and identification of bioactive constituent from Crateva magna Lour. (DC) and Its effect on Urolithiasis. PhD thesis Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore-641043.
![](https://i-scholar.in/public/site/images/abstractview.png)
Abstract Views: 320
![](https://i-scholar.in/public/site/images/pdfview.png)
PDF Views: 15