Smilax chinensis Linn. (Liliaceae) Root Attenuates Insulin Resistance and Ameliorate Obesity in High Diet Induced Obese Rat

High fat diet a prominent reason for obesity leads to overweight and insulin resistance. The objective of the present study was to evaluate antiobesity of Smilax chinensis through attenuating insulin resistance inn high fat diet induced obese rat. High fat diet induced obese rats were treated with S. chinensis methanol extract (SCME) for the 8 weeks at two different dosses 100 and 200 mg /kg orally. Administration of SCME significantly decreased body weight, food intake and fat depot. Furthermore SCME reversed lipid metabolism to near normal and significantly decreased glucose, plasma insulin and leptin levels and decreased insulin resistance. Histological analysis of adipose tissue decreased the size of adipose tissue further proves the anti-obesity property of SCME.