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Authors
Affiliations
1 Department of Biochemistry, Sree Narayana Guru College, Coimbatore-641 021, Tamil Nadu, IN
2 Department of Soil Science and Agricultural Chemistry, Anbil Dharmalingum Agricultural College and Research Institute, Trichy 620009, Tamil Nadu, IN
3 Department of Biochemistry, Karpagam University, Coimbatore 641 021, Tamil Nadu, IN
Source
South Indian Journal of Biological Sciences, Vol 1, No 2 (2015), Pagination: 60-65
Abstract
Alysicarpus vaginalis (L.) DC commonly known as Alyce clover, belongs to the botanical family Fabaceae. It is widely distributed in India, Pakistan, Sri Lanka , Africa and Australia. In India it is traditionally used by the tribals for diuretics, leprosy, pulmonary troubles and back pain. The present study aimed to evaluate the hepatoprotective activity of ethanol extract of A. vaginalis aerial parts in nitrobenzene (NB) induced hepatic injury in Wistar rats. Liver injury was induced in rats by single oral administration of of NB (50 mg/kg bw). One days after NB induction, the rats were treated with ethanolic extract of A. vaginalis orally at the doses of 200 mg/kg bw daily for 30 days. Silymarin (25 mg/kg bw orally) was used as reference drug. After 30 days serum biochemical parameters, antioxidant enzyme status and histopathological parameters were analyzed. The results indicated that the ethanol extract of A. vaginalis the doses of 200 mg/kg orally significantly (P<0.05) and dose-dependently reduced and normalized the serum marker enzymes, and increased the antioxidant enzyme status as compared to that of NB control group. Further more it was confirmed by histopathological studies. This study concludes that A. vaginalis demonstrated promising hepatoprotectivity agent in NB induced hepatic damaged rats.
Keywords
Alysicarpus vaginalis, Antioxidant Enzymes, Liver Injury, Liver Marker Enzymes, Nitrobenzene.
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