Effect of Chromium Supplementation on Insulin Resistance and Weight Reduction in Polycystic Ovarian Syndrome Cases

Polycystic ovary syndrome (PCOS) has some degree of insulin resistance. Chromium picolinate, improves insulin sensitivity at the insulin receptor level without adverse effects but was not tested in ovulation .A randomized controlled study was conducted in shatby Maternity hospital, Alexandria where hundred PCOS cases with body mass index between 30 and 34.5 were divided into two groups: GroupA; 50 cases received chromium 600 mcg and Group B; 50 cases did not receive chromium. All participants received clomiphene citrate for three cycles to induce ovulation and were followed up for: body mass index, follicular maturation and Pregnancy. There was a statistically significant difference in body mass index, fasting blood sugar, ovulation and pregnancy in the chromium group. Chromium picolinate improved insulin resistance, ovulation and pregnancy in polycystic ovarian syndrome.