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Studies on Thermophysical Properties of Bronsted Acidic Ionic Liquids for Medical Applications


Affiliations
1 Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, IR, Iran, Islamic Republic of
 

Drug Ionic liquids have been widely studied in Medicine for the replacement of VOCs in organic chemistry for the synthesis of biologically active compounds including Active Pharmaceutical Ingredients (APIs). ILs and antimicrobial or antibacterial activity, antibiofilm activity, ILs and antitumor activity, biotechnology and toxicity of ionic liquids, and biomedical applications (use of ILs to boosting MRI), all these are important for Medical applications. To overcome problems pharmaceutical process, ionic liquids (ILs) have been increasingly exploited as solvents and or (co) solvents and or reagents in a wide range of pharmaceutical applications due to their tailormade chemical, physical and biological properties. The Bronsted Acidic Ionic Liquids (BAILs) [Bu3NH]H2PO4, [Bu3NH]HSO4, [Bu3NH]NO3, [Bu3NH]Cl, were synthesized and characterized instruments tending: TLC, FT-IR, 1H-NMR and elemental analysis. Experimental densities(ρ)dynamic viscosities (η), surface tension (σ), electrical conductivity (κ), refractive indices (nD) and thermal conductivity (λ), that were investigated as a function of temperature under (293.15 to 363.15) K conditions, for binary systems with water ionic liquids at atmospheric pressure. A standard and effective method to evaluate the acidity of Bronsted acids was the Hammett method (Ho) which might use them for BAILs, pH and pKa. Conjointly, densities, dynamic viscosity, surface tension, ionic conductivity, refractive indices and thermal conductivity deviations, and dynamic viscosity deviations in for the binary systems with water were fitted to a Vogel-Fulcher-Tammann (VFT) equation. The current synthesized ionic liquids show a weak temperature dependency on the physical properties.

Keywords

Ionic Liquids, Medical Chemistry, Pharmaceutical Salts, Physical Properties, Temperature Dependence, Water, Molecular Interactions.
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  • Studies on Thermophysical Properties of Bronsted Acidic Ionic Liquids for Medical Applications

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Authors

Zeinab Heidari Pebdani
Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, IR, Iran, Islamic Republic of

Abstract


Drug Ionic liquids have been widely studied in Medicine for the replacement of VOCs in organic chemistry for the synthesis of biologically active compounds including Active Pharmaceutical Ingredients (APIs). ILs and antimicrobial or antibacterial activity, antibiofilm activity, ILs and antitumor activity, biotechnology and toxicity of ionic liquids, and biomedical applications (use of ILs to boosting MRI), all these are important for Medical applications. To overcome problems pharmaceutical process, ionic liquids (ILs) have been increasingly exploited as solvents and or (co) solvents and or reagents in a wide range of pharmaceutical applications due to their tailormade chemical, physical and biological properties. The Bronsted Acidic Ionic Liquids (BAILs) [Bu3NH]H2PO4, [Bu3NH]HSO4, [Bu3NH]NO3, [Bu3NH]Cl, were synthesized and characterized instruments tending: TLC, FT-IR, 1H-NMR and elemental analysis. Experimental densities(ρ)dynamic viscosities (η), surface tension (σ), electrical conductivity (κ), refractive indices (nD) and thermal conductivity (λ), that were investigated as a function of temperature under (293.15 to 363.15) K conditions, for binary systems with water ionic liquids at atmospheric pressure. A standard and effective method to evaluate the acidity of Bronsted acids was the Hammett method (Ho) which might use them for BAILs, pH and pKa. Conjointly, densities, dynamic viscosity, surface tension, ionic conductivity, refractive indices and thermal conductivity deviations, and dynamic viscosity deviations in for the binary systems with water were fitted to a Vogel-Fulcher-Tammann (VFT) equation. The current synthesized ionic liquids show a weak temperature dependency on the physical properties.

Keywords


Ionic Liquids, Medical Chemistry, Pharmaceutical Salts, Physical Properties, Temperature Dependence, Water, Molecular Interactions.

References