SMU Medical Journal

Open Access Open Access  Restricted Access Subscription Access

Caffeic Acid-A Potent Phytocompound against Diabetes Mellitus a Review


Affiliations
1 Department of Physiology, Sikkim Manipal Institute of Medical Sciences, 5th Mile, Tadong, Gangtok, India
2 Department of Microbiology, Sikkim University,Tadong, Gangtok, India
3 Department of Pharmacology, Sikkim Manipal Institute of Medical Sciences, 5th Mile, Tadong, Gangtok, India
 

Diabetes mellitus, a metabolic syndrome characterized by chronic hyperglycemia causes serious morbidity and mortality worldwide. Several allopathic drugs are available to treat diabetes but management without any side effects is still a challenge to the medical system; hence phytocompounds are getting more importance. Number of plant based compounds has been identified as potential antidiabetics. Caffeic acid, isolated from edible plant species has wide range of pharmacological effects. Recently, antidiabetic activities of caffeic acid are being explored. This review of the current literature discuss in detail about the antidiabetic actions of caffeic acid, including; antidegenerative effect on islets, up-regulation adipocytes GLUT-4, inhibition of alpha-amylase and alpha-glucosidase activity, increase mRNA expression of glucokokinase, decrease in glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities and regulation of beta-cell function.

Keywords

Antidiabetic Activities, Caffeic Acid, Diabetes Mellitus.
User
Notifications
Font Size

Abstract Views: 275

PDF Views: 344




  • Caffeic Acid-A Potent Phytocompound against Diabetes Mellitus a Review

Abstract Views: 275  |  PDF Views: 344

Authors

Bibhushan Dhungyal
Department of Physiology, Sikkim Manipal Institute of Medical Sciences, 5th Mile, Tadong, Gangtok, India
Pramila Koirala
Department of Microbiology, Sikkim University,Tadong, Gangtok, India
Chandrakala Sharma
Department of Pharmacology, Sikkim Manipal Institute of Medical Sciences, 5th Mile, Tadong, Gangtok, India
D. K. Jha
Department of Physiology, Sikkim Manipal Institute of Medical Sciences, 5th Mile, Tadong, Gangtok, India

Abstract


Diabetes mellitus, a metabolic syndrome characterized by chronic hyperglycemia causes serious morbidity and mortality worldwide. Several allopathic drugs are available to treat diabetes but management without any side effects is still a challenge to the medical system; hence phytocompounds are getting more importance. Number of plant based compounds has been identified as potential antidiabetics. Caffeic acid, isolated from edible plant species has wide range of pharmacological effects. Recently, antidiabetic activities of caffeic acid are being explored. This review of the current literature discuss in detail about the antidiabetic actions of caffeic acid, including; antidegenerative effect on islets, up-regulation adipocytes GLUT-4, inhibition of alpha-amylase and alpha-glucosidase activity, increase mRNA expression of glucokokinase, decrease in glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities and regulation of beta-cell function.

Keywords


Antidiabetic Activities, Caffeic Acid, Diabetes Mellitus.