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Increase in Nalidixic Acid Resistance among Salmonella enterica Isolates Recovered from Patients in Tehran, Iran
One hundred thirty eight S. enterica isolates were collected; of those, 89 (64%) were resistant to nalidixic acid. The percentage of isolates resistant to nalidixic acid was 59% (19/32) in 2006, 64% (34/53) in 2007, and 67% (36/53) in 2008. The most common multidrug resistance phenotype amongst nalidixic acid-resistant isolates was resistance to doxycycline, kanamycin, neomycin, streptomycin, sulfamethoxazole, and tetracycline. We found nalidixic acid resistance is increasing amongst nontyphoidal S. enterica isolates in our study. Over the past 3 years, there has been a significant increase in the proportion of nalidixic acid resistant S. enterica. Continued surveillance of antimicrobial resistance among S. enterica is needed to mitigate the increasing prevalence of nalidixic acid resistance among Salmonella.
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