Author Details

Scroll

Refine your search

Collections

Medical Collection

Co-Authors

Journals

SMU Medical Journal

Year

2015
2014

Authors

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All

Ravikant,

Nanobacteria - Present Status and Role in Human Diseases

Abstract Views :184 | PDF Views:216

Authors

Maninder Kaur ¹, Ravikant ¹, Satish Gupte ², Prerna Aggrawal ¹, Ashwini Manahas ¹, Manju Arora ¹

Affiliations
1 Department of Microbiology, Gian Sagar Medical College & Hospital, Punjab, 140601, IN
2 Department of Microbiology, GianSagar Medical College and Hospital, Banur, Punjab, IN

Source

SMU Medical Journal, Vol 2, No 2 (2015), Pagination: 241-248

Abstract

The status of nanobacteria has been controversial, with some researchers suggesting they are a new class of living organism and others attributing to them a simpler, abiotic nature. They appear to be ubiquitous entities found in living and non-living substrates. Research has suggested that nanobacteria could be the cause of a wide variety of diseases, from kidney stones to atherosclerosis.

Full Text

References

Kajander, E.O.; Ciftcioglu, N. (1998). Nanobacteria: An alternative mechanism for pathogenic intra- and extracellular calcification and stone formation. Proc. Natl. Acad. Sci. USA, 95(14), 8274-8279.

Mckay D N, Mathew G, Kajander E (2006). "Nanobacteria: Fact Or Fiction? Characteristics, Detection, And Medical Importance Of Novel Self-Replicating, Calcifying Nanoparticles". J Investig Med 54 (7): 385-94

Hopkin M.Nanobacteria theory takes a hit.http://www.nature.com/news/2008/080417/full/news.2008.762

Ciftcioglu, N.; Bjorklund, M.; Kuorikoski, K.; Kajander, E.O. (1999).Nanobacteria: an infectious cause for kidney stone formation. Kidney Int., 56(5), 1893-1898

McKay, David S.; et al. (1996). "Search for Past Life on Mars: Possible Relic Biogenic Activity in Martian Meteorite ALH84001". Science 273 (5277): 924-930

Ciftcioglu, N., Kuronen, I., Åkerman, K., Hiltunen, E., Laukkanen, J. & Kajander. E. O. (1997) in Vaccines 97, eds. Brown, F., Burton, D., Doherty, P., Mekalanos, J. & Norrby, E. (Cold Spring Harbor Lab. Press, Cold Spring Harbor, NY), pp. 99-103.

Uwins P J, Webb RI, and Taylor AP.(1998) Novel nano-organisms from Australian sandstones American Mineralogist, Volume 83, pages 1541-1550

Martel J, Young JD; Young (April 2008). "Purported nanobacteria in human blood as calcium carbonate nanoparticles". Proc. Natl. Acad. Sci. U.S.A. 105(14): 5549-54.

Kajander E O, Tahvanainen E, Kuronen I, Ciftcioglu N (1994) Zentralbl Bakteriol .Suppl126:147-149

García-Cuerpo E, Kajander EO, Ciftcioglu N, et al.(2000) Nanobacteria: Un modelo de neo-litogenesis experimental. Arch. Esp. de Urol., 53:291-303.

Miller VM, Rodgers G, Charlesworth JA, Kirkland B, Severson SR, Rasmussen TE, et al. (2004) Evidence of nanobacterial-like structures in calcified human arteries and cardiac valves. Am J Physiol Heart Circ Physiol 287:H1115e24.

Ciftcioglu N, Kajander EO.(1998) Interaction of Nanobacteria with cultured mammalian cells. Pathophysiology 4:259-270.

An overview on clinical implications of nanobacteria.Kumar CA, Bagga MB, Mohan V and Raghav N. (2011) J of Indian Academy of oral medicine and radiology,July 23(3)S354-359

Moe OW. (2006) Kidney stones: pathophysiology and medical management. Lancet 367:333e44

Aloisi G. (2008) An alternative origin for nanobacteria in kidney stones.Bioscience Hypotheses 1, 138e141

Aloisi G, Gloter A, Kruger M, Wallmann K, Guyot F, Zuddas P (2006) Nucleation of calcium carbonate on bacterial nanoglobules. Geology 34(12):1017e20.

Kajander EO. (2006) Nanobacteria-propagating calcifying nanoparticles.Lett Appl Microbiol. 42:549e52.

Puskas LG, Tiszlavicz L, Razga Z, et al. (2005) Detection of nanobacteria-like particles in human atherosclerotic plaques. Acta Biol Hung 56: 233-245.

Sedivy R, Battistutti WB. (2003) Nanobacteria promote crystallizationof psammoma bodies in ovarian cancer. AMPIS 111:951e4.

Maniscalco BS, Taylor KA. (2004) Calcification in coronary artery disease can be reversed by EDTA-tetracycline long-term chemotherapy. Pathophysiology 11:95-101.

Blaizot A, Vergnes JN, Nuwwareh S. (2009) Peri odontal diseases and cardiovascular events:Meta analysis of observational studies.Int Dent J 59:197-209

Environmental Pathogens Related to Human Infections

Abstract Views :174 | PDF Views:115

Authors

Tanveer Kaur ¹, Satish Gupte ¹, Mandeep Kaur ¹, Ravikant ¹

Affiliations
1 Department of Microbiology, Gian Sagar Medical College & Hospital, Rajpura, IN

Source

SMU Medical Journal, Vol 2, No 2 (2015), Pagination: 286-294

Abstract

Environmental pathogens are microorganisms that normally spend a substantial part of their lifecycle outside human hosts, but when introduced to humans cause diseases. They are borne in the water, soil, air, food, and other elements of our surroundings. Their adverse effects on human health cannot be controlled without first obtaining a thorough understanding of their environmental habitats and the epidemiology of the diseases they cause. To achieve this understanding, surveillance of the environment to determine the numbers and distribution of environmental pathogens is needed. The impacts of environmental pathogens can be felt by almost every person, So the public needs to be made better aware of their presence and risks. More study and research is needed on these environmental microbes for appropriate drug and vaccine development for the control of these infections. This review article highlights some of important environmental microbes associated with human infections.

Keywords

Environmental Pathogens, Fomites, Biofilms, Aerosols.

Full Text

References

Falkinham, J.O. (2009) III Surrounded by mycobacteria: nontuberculous mycobacteria in the human environment. J. Appl. Microbiol. 107, 356-367.

Inderlied, C.B., Kemper C.A. and Bermudez, L.E. (1993) The Mycobacterium avium complex. Clin. Microbiol. Rev. 6, 266-310.

Falkinham J.O.(2011) III Nontuberculous mycobacteria from household plumbing of patients with nontuberculous mycobacteria disease. Emerg. Infect. Dis. 17,419-424.

Bukh, A.S. and Roslev, P. (2014) Mycobacterium avium complex in day care hot water systems, and persistence of live cells and DNA in hot water pipes. Curr. Microbiol. 68, 428-439.

George, K.L., Parker, B.C., Ruft, H. and Falkinham, J.O. (1980) Epidemiology of infection by nontuberculous mycobacteria. Growth and survival in natural waters. Am. Rev. Respir. Dis. 122, 89-94.

Norton, C.D., LeChevallier, M.W. and Falkinham, J.O. (2004) Survival of Mycobacterium avium in a model distribution system. Water Res. 38, 1457-1466.

Embil, J., Warren, P., Yakrus, M., Stark, R., Corne, S., Forrest, D. and Hershfield, E. (1997) Pulmonary illness associated with exposure to Mycobacterium-avium complex in hot tub water. Chest. 111, 813-816.

Sugita, Y. (2000) Familial cluster of cutaneous Mycobacterium avium infection resulting from use of a circulating, constantly heated bath water system. Br. J. Dermatol. 142, 789.

Hugh-Jones, M. and Blackburn, J. (2009) The ecology of Bacillus anthracis. Molecular Aspects of Medicine. 30, 356-367.

Blackburn, J.K., McNyset, K.M., Curtis, A., Hugh-Jones, M.E.((2007) Modeling the geographic distribution of Bacillus anthracis, the causative agent of anthrax disease, for the contiguous United States using predictive ecologic niche modeling. The American journal of tropical medicine and hygiene. 77, 1103- 1110.

Joyner, T.A., Lukhnova, L., Pazilov, Y., Temiralyeva, G., Hugh-Jones, M.E. et al.(2010) Modeling the potential distribution of Bacillus anthracis under multiple climate change scenarios for Kazakhstan. PloS one 5, e9596.

Mullins, J., Lukhnova L., Aikimbayev A., Pazilov Y., Van Ert M. et al.(2011) Ecological Niche Modelling of the Bacillus anthracis A1. a sub-lineage in Kazakhstan. BMC ecology. 11, 32.

Christie, A.B. (1987) Anthrax. Infectious Diseases: Epidemiology and Clinical Practice. Edinburgh: Churchill Livingstone. 4, 100-164.

Nguyen, V.T., Fegan, N., Turner, M.S., Dykes, G.A. (2012) Role of attachment to surfaces on the prevalence and survival of Campylobacter through food systems. J. Food Prot. 75,195-206, .

Joshua, G.W.P., Guthrie-Irons, C., Karlyshev, A.V., Wren, B.W.(2006) Biofilm formation in Campylobacter jejuni. Microbiology. 152:387-396.

Stanley, K., and Jones, K.(2003) Cattle and sheep farms as reservoirs of Campylobacter. J.Appl. Microbiol. 94, 104S-113S.

Taylor, E. V., Herman, K. M., Ailes, E. C. Fitzgerald, C., Yoder, J. S., Mahon, B. E. and Tauxe, R. V. (2013) Common source outbreaks of Campylobacter infection in the USA, 1997-2008.Epidemiol. Infect.141, 987-996.

Park, S.F. (2002) The physiology of Campylobacter species and its relevance to their role as foodborne pathogens. Int. J. Food Microbiol. 74,177-188.

Martinez-Rodriguez, A., Kelly, A.F., Park, S.F., Mackey B.M.(2004) Emergence of variants with altered survival properties in stationary phase cultures of Campylobacter jejuni. Int. J. Food Microbiol. 90, 321-329.

Baylis, C.L., MacPhee, S., Martin, K.W., Humphrey, T.J. and Betts, R.P. (2000) Comparison of three enrichment media for the isolation of Campylobacter spp. from foods. J. Appl. Microbiol. 89, 884-891.

Buswell, C.M., Herlihy, Y.M., Lawrence L.M., McGuiggan, J.T.M., Marsh, P.D., Keevil, C.W., Leach, S.A. (1988) Extended survival and persistence of Campylobacter spp. in water and aquatic biofilms and their detection by immunofluorescent- antibody and -rRNA staining. Appl. Environ.Microbiol. 64, 733-742.

Hadler, J.L. (2014) Legionnaires’ disease caused by Legionella pneumophila Serogroups 5 and 10. China Emerging Infectious Diseases. www.cdc.gov/eid . Vol. 20, 7,1242-1243.

Gerard, A., Cangelosi, Nancy, E., Freitag, and Buckley, M.R. From outside to inside: Environmental microbes as human pathogens. 2005.Colloquium Report. American Academy of Microbiology, held onFebruary 6-8, 2004, in Portland, Oregon.

Kim, C., Jeon,S., Jung,J. et al.(2015) Isolation of Legionella pneumophila from cooling towers, public baths, hospitals, and fountains in seoul, korea, from 2010 to 2012. Journal of Environmental Health. 77(6), 58-62.

ILSI Research Foundation, & Risk Science Institute Expert Panel on Listeria monocytogenes in Foods. Achieving continuous improvement in reductions in foodborne listeriosis-a risk-based approach. Journal of Food Protection. (2005), 68(9), 1932-1994.

El-Shenawy, M.A., and El-Shenawy, M.A. (2006) Listeria spp. in the coastal environment of the Aqaba Gulf, Suez Gulf, and the Red Sea. Epidemiology and Infection. 134(4), 751-757.

Hellstrom, S., Kiviniemi, K., Autio, T., and Korkeala, H. (2008) Listeria monocytogenes is common in wild birds in Helsinki region and genotypes are frequently similar with those found along the food chain. Journal of Applied Microbiology.104(3), 883-888.

Thimothe, J., Nightingale, K.K., Gall, K., Scott, V.N., and Wiedmann, M. (2004) Tracking of Listeria monocytogenes in smoked fish processing plants. Journal of Food Protection. 67(2), 328-341.

Vazquez-Salinas, C., Rodas-Suarez, O., and Quinones-Ramirez, E.I. (2001) Occurrence of Listeria monocytogenes species in raw milk in farms on the outskirts of Mexico City. Food Microbiology. 18(2), 177-181.

Tompkin, R.B.(2002) Control of Listeria monocytogenes in the food-processing environment.Journal of Food Protection. 65(4),709-725.

Doyle, M.E., Mozzotta, A.S., Wang, T., (2001) Wiseman, D.W. and Scott, V.N. Heat resistance of Listeria monocytogenes. Journal of Food Protection. 64(3), 410-429.

Waak, E., Tham, W., and Danielsson-Tham, M.L. (2002) Prevalence and fingerprinting of Listeria monocytogenes strains isolated from raw whole milk in farm bulk tanks and dairy plant receiving tanks. Applied and Environmental Microbiology. 68(7), 3366-3370.

Current Concepts of Commonly Used Vaccines

Abstract Views :191 | PDF Views:105

Authors

Ravikant ¹, Satish Gupte ², Manju Bala ¹, Tanveer Kaur ¹, Mandeep Kaur ¹

Affiliations
1 Department of Microbiology, Gian Sagar Medical College & Hospital, Rajpura, IN
2 Department of Microbiology, GianSagar Medical College and Hospital, Banur, Punjab, IN

Source

SMU Medical Journal, Vol 2, No 2 (2015), Pagination: 306-316

Abstract

Today's world need vaccines for the prevention of infectious diseases, cancer therapy, and many more. Vaccines reduce the mortality rates in the world from infectious diseases such as measles, polio and diphtheria. The concept of vaccination is very old. Conventional vaccines are composed of Live or Attenuated microorganisms. But they may not be sufficient in current scenario, so further research is going on for development of vaccine which should be cost-effective and having specific immune responses. The current concept of vaccines is a challenge which could produce both humoral and cell-mediated immunity. In this review we are discussing about the types, concept, economics, and newer trends for vaccines production.

Keywords

Vaccines, Types, Concept, Trends.

Full Text

References

Judy owen , jenni punt & Sharon stranford, M.(2013) kuby immunology :vaccine, 7th Ed.US: W.H.freeman.ISBN-9781464137846

Pasteur, Louis (1881). "Address on the Germ Theory". Lancet 118 (3024): 271-2.doi:10.1016/s0140-6736(02)35739-8.

"Vaccine Types". Niaid.nih.gov. 2012-04-03. Retrieved 2013-04-26.

Kim W, Liau LM (2010). "Dendritic cell vaccines for brain tumors". Neurosurg Clin N Am21 (1): 139–57. doi:10.1016/j.nec.2009.09.005. PMC 2810429. PMID 19944973.

Meri, S; Jördens, M; Jarva, H (2008). "Microbial complement inhibitors as vaccines". Vaccine. 26 Suppl 8: I1137. doi:10.1016/j.vaccine.2008.11.058.PMID 19388175.

Jit, Mark; Newall, Anthony T.; Beutels, Philippe (2013). "Key issues for estimating the impact and cost-effectiveness of seasonal influenza vaccination strategies". Human vaccines & immunotherapeutics 9 (4): 834–840. doi:10.4161/hv.23637.

"Thimerosal in vaccines". Center for Biologics Evaluation and Research, U.S. Food and Drug Administration. 2007-09-06. Retrieved 2007-10-01.

Plotkin SA (2005). "Vaccines: past, present and future". Nat Med 11 (4 Suppl): S5– 11. doi:10.1038/nm1209. PMID 15812490.

"Safer vaccine created without virus". March 28, 2013. Retrieved March 28, 2013.

Sala, F.; Manuela Rigano, M.; Barbante, A.; Basso, B.; Walmsley, AM; Castiglione, S (2003). "Vaccine antigen production in transgenic plants: strategies, gene constructs and perspectives". Vaccine 21 (7–8): 803–8. doi:10.1016/s0264-410x(02)006035. PMID 23888738.

Kumar, G. B. Sunil; T. R. Ganapathi, C. J. Revathi, L. Srinivas and V. A. Bapat (2005). "Expression of hepatitis B surface antigen in transgenic banana plants". Planta222 (3): 484–493. doi:10.1007/s00425-005-1556-y. PMID 15918027

Influenza A (H1N1) 2009 Monovalent Vaccine http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm181950.htm

AIDSinfo Vaccine Web page at http://aidsinfo.nih.gov/ Vaccines/

Zhang VM, Chavchich M, Waters NC (2012). "Targeting protein kinases in the malaria parasite: update of an antimalarial drug target". Curr Top Med Chem 12 (5): 456– 72. doi:10.2174/156802612799362922. PMID 22242850.

Prabowo, S. et al. (2013) "Targeting multidrug-resistant tuberculosis (MDR-TB) by therapeutic vaccines." Med Microbiol Immunol 202: 95-1041. Print.

White, A. et al. (2013) "Evaluation of the Safety and Immunogenicity of a Candidate Tuberculosis Vaccine, MVA85A, Delivered by Aerosol to the Lungs of Macaques." Clinical and Vaccine Immunology 20 : 663-672.

Current Concept of New-Delhi Metallo Beta Lactamases (NDM)

Abstract Views :223 | PDF Views:171

Authors

Ravikant ¹, Satish Gupte ², Prerna Aggarwal ¹, Maninder Kaur ³, Ashwini Manhas ¹, Manju Arora ¹, Mrinangka Dev ¹

Affiliations
1 Department of Microbiology, Gian Sagar Medical College & Hospital, Banur, Punjab, IN
2 Gian Sagar Medical College & Hospital, IN
3 Department of Microbiology, Gian Sagar Medical College & Hospital, Banur, Punjab

Source

SMU Medical Journal, Vol 1, No 2 (2014), Pagination: 88-101

Abstract

The emergence of superbugs intermittently has always been a global threat for control and treatment of infectious disease caused by them over many decades which influence human population with their mutated genetic make-up and mechanics of resistance. However, bacteria have been developing resistance to antibiotics since they were introduced in 1930s. From the year 1961 till date, among some of the more common superbugs are methicillin-resistant Staphylococcus aureus (MRSA) and drug resistant tuberculosis (MDR-TB and XDR-TB). The latest superbug encodes the gene for New Delhi metallo-beta-lactamase (NDM-1) is an enzyme that can hydrolyze and inactivate carbapenems, which are used as a last resort for the treatment of multi-resistant bacterial infection. Escherichia coli and Klebsiella pneumoniae commonly expresses the gene for NDM-1 moreover NDM-2 in Acinetobacter baumannii, NDM-4, NDM-5, NDM- 6, NDM-7 and NDM-8 from E.coli and other Enterobacteriaceae also have been reported. Research is on to develop new classes of antibiotic to handle these threats and it is worrying as there are very limited therapeutics available in the development pipeline that works effectively in the current situation.

Username
Password
Remember me