SMU Medical Journal

Nnodim Johnkennedy ¹, C. Meludu Samuel ², C. E. Dioka ³, Martin Ifeanyichukwu ⁴, Okorie Hope ¹, G. C. Uloneme ⁵

Affiliations
1 Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, NG
2 Department of Human Biochemistry, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001 Nnewi, Anambra State, NG
3 Department of Chemicalpathology, College of Medicine and Health Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, NG
4 Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, NG
5 Department of Human Anatomy, Imo State University, Owerri, Imo State, NG

Abstract

The study was carried out to determine the level of leptin and C-peptide in sickle cell anemia. Thirty confirmed sickle cell patients in steady state(HbSS-SS) and thirty normal haemoglobin (HbAA) as well as sixteen sickle cell disease in crises(HbSS-cr) between the ages of 15 to 30 years were selected in this study. Leptin and C-peptide were measured by commercially available ELISA kits. The results obtained showed that the levels of leptin and C-peptide in Sickle cell anaemia patients were significantly elevated when compared with HbAA subjects (P<0.05). However, the level of leptin and C-peptide in sickle cell steady state were highly significant when compared with those in crisis(P<0.05). This may probably implies that leptin and C-peptide decrease could enhance sickle cell crisis. Also, it could provide the understanding of the possible role of leptin and C-peptide in the pathophysiology of sickle cell anaemia.

Keywords

Leptin, C-Peptide , Sickle Cell Anaemia, Pathophysiology.

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