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Ghosh, Tanaya
- Anti Peptic Ulcer Activity of Tea Leaves
Abstract Views :336 |
PDF Views:136
Authors
Affiliations
1 Department of Biochemistry, North Bengal Medical College, Sushrutanagar - 734012 Dist. Darjeeling, West Bengal, IN
1 Department of Biochemistry, North Bengal Medical College, Sushrutanagar - 734012 Dist. Darjeeling, West Bengal, IN
Source
SMU Medical Journal, Vol 2, No 2 (2015), Pagination: 192-214Abstract
Anti peptic ulcer activity of tea leaves was checked in cysteamine induced duodenal ulcer and ethanol, hydrochloric acid, aspirin, indomethacin, swimming stress, pyloric ligation and restraint induced gastric ulcer models in albino rats. Ranitidine, a conventional anti peptic ulcer drug, was used for comparison. Results showed that tea leaves powder could reduce ulcer index significantly (p<0.001) in all the experimental ulcer models studied and the results were comparable to that of ranitidine.Keywords
Tea Leaves, Anti Gastric Ulcer Activity, Experimental Gastric Ulcer Models.Full Text
References
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- Anti Gastric Ulcer Activity of Amaranthus spinosus Linn. Leaves in Aspirin Induced Gastric Ulcer in Rats and the Underlying Mechanism
Abstract Views :357 |
PDF Views:144
Authors
Affiliations
1 Department of Biochemistry, North Bengal Medical College, Sushrutanagar 734012, Dist. Darjeeling, West Bengal, IN
2 Biotechnology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
1 Department of Biochemistry, North Bengal Medical College, Sushrutanagar 734012, Dist. Darjeeling, West Bengal, IN
2 Biotechnology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
Source
SMU Medical Journal, Vol 1, No 2 (2014), Pagination: 313-328Abstract
Problems: Search for new drugs of gastric ulcer. Experimental approach: Anti gastric ulcer activity of Amaranthus spinosus Linn. in aspirin induced gastric ulcers was studied in rats. Findings: Results showed that Amaranthus spinosus Linn. leaves significantly reduced ulcer index induced by aspirin. The plant leaves produced gastric anti secretory effect by decreasing gastric volume and acidity. Elevated level of gastric pepsin during aspirin induced ulcers was found lowered by the leaves indicating its involvement in offensive mechanism in production of gastric ulcer. Leaves further increased gastric mucin which showed its gastric cytoprotective effect. The plant leaves prevented loss of gastric protein, DNA and the increased lipid peroxidation during ulceration by aspirin. Activities of the anti oxidant enzymes were enhanced during ulceration by this plant leaves. Results were comparable to that of ranitidine, a standard anti ulcer drug. Conclusion: Anti ulcerogenic activity of Amaranthus spinosus Linn. leaves was mediated through anti oxidant defense mechanism.Keywords
Amaranthus spinosus Linn, Aspirin, Ranitidine, Gastric Ulcer, SOD, CAT, GSH.Full Text
- Isolation of Antiulcerogenic Compound (AC-I) from Ageratum conyzoides L. Leaves and Effect of Season on Yield of the Compound
Abstract Views :174 |
PDF Views:130
Authors
Affiliations
1 Department of Biochemistry, North Bengal Medical College, Siliguri, Dist. Darjeeling, West Bengal, IN
1 Department of Biochemistry, North Bengal Medical College, Siliguri, Dist. Darjeeling, West Bengal, IN
Source
SMU Medical Journal, Vol 2, No 1 (2015), Pagination: 221-237Abstract
A compound (AC-I) was isolated from Ageratum conyzoides L. leaves. The compound had anti peptic ulcer activity in ethanol induced gastric ulcers and cysteamine induced duodenal ulcers in albino rats. Seasonal variation in concentration of the compound (AC-I) in A. conyzoides L. leaves was studied. Results showed that leaves of A. conyzoides L. for the months of July and August yielded maximum amount of the compound.Keywords
Ageratum conyzoides L. Leaves, Peptic Ulcer, Ethanol, Cysteamine, Ranitidine, Ulcer Index.Full Text
- Seasonal Variation in Hepatoprotective Activity of Titeypati (Artemisia vulgaris L. ) Leaves on Antitubercular Drugs Induced Hepatotoxicity in Rats.
Abstract Views :232 |
PDF Views:157
Authors
Affiliations
1 Department of Biochemistry, North Bengal Medical College, Sushrutanagar - 734012 Dist. Darjeeling, West Bengal, IN
1 Department of Biochemistry, North Bengal Medical College, Sushrutanagar - 734012 Dist. Darjeeling, West Bengal, IN
Source
SMU Medical Journal, Vol 3, No 1 (2016), Pagination: 763-774Abstract
Plant Titeypati (Artemisia vulgaris L.), belongs to the family Asteraceae, is abundant in Sikkim and Darjeeling Himalayas in the middle and upper hill forest up to the height of 2000-5000 ft. Titeypati is a medicinal plant traditionally used to treat a wide range of diseases. Hepatoprotective activity of Titeypati has been noted in hepatotoxicity in rats. Seasonal variation in this effect, if any, was studied. Results showed that Titeypati leaves during the period May - June had maximum protective effect on anti tubercular drugs induced hepatotoxicity in rats.Keywords
Titeypati, Artemisia vulgaris L., Hepatotoxicity, Anti Tubercular Drugs.Full Text
- In vitro Anti Thiamine Activity of an Isolated Compound from Murrya koenigii (linn.) Spreng Wettst Leaves:Effect of Season
Abstract Views :311 |
PDF Views:144
Authors
Affiliations
1 Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, IN
2 Department of Medical Biotechnology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
1 Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, IN
2 Department of Medical Biotechnology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
Source
SMU Medical Journal, Vol 4, No 1 (2017), Pagination: 128-141Abstract
By solvent extraction, acid hydrolysis, chromatographic experiments followed by crystallization a compound was isolated from Murrya koenigii (Linn.) Spreng Wettst leaves. The compound could exert anti thiamine activity in in vitro experiment. It was found out that 1g of the compound inactivated 31.8 mg of thiamine hydrochloride in 1 h. Effect of season on in vitro anti thiamine activity of the compound was also studied. Results showed that compound isolated from the leaves of Murrya koenigii (Linn.) Spreng Wettst of the period July - August had maximum anti thiamine activity.
Keywords
Murrya koenigii (Linn.) Spreng Wettst Leaves, Anti Thiamine Activity, Seasonal Variation.Full Text
- In Vitro Anti Oxidant Activity of Chromatographically Separated Fractions from the Leaves of Aastilbe rivularis Buch. - Ham. Ex D. Don
Abstract Views :198 |
PDF Views:158
Authors
Affiliations
1 Department of Medical Biotechnology, Sikkim Manipal University, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
2 Department of Biochemistry, Sikkim Manipal University, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
1 Department of Medical Biotechnology, Sikkim Manipal University, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
2 Department of Biochemistry, Sikkim Manipal University, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
Source
SMU Medical Journal, Vol 3, No 2 (2016), Pagination: 226-239Abstract
In vitro antioxidant activity of chromatographically separated fractions from powdered leaves of Aastilbe rivularis buch. - Ham. Ex D. Don was studied. Antioxidant activity was measured by superoxide anion generation with help of xanthine-xanthine oxidase assay and with linoleic acid peroxidation assay as well as DPPH photometric assay. Total phenol, flavonoids, ascorbic acid and carotenoid contents in the separated fractions were also estimated. Out of five fractions separated, the third fraction had maximuum antioxidant activity which was comparable to that of known synthetic antioxidant. Antioxidant activity was related with high content of total phenol, flavonoid, ascorbic acid and carotenoids in the fraction.Keywords
Astilbe rivularis, Buch. - Ham. Ex D. Don, Chromatographic Separation, Anti Oxidant Activity, Total Phenol, Flavonoid, Ascorbic Acid.Full Text
- Effect of Season on In vitro Anti Oxidant Activity of Aageratum conyzoides L. Leaves
Abstract Views :456 |
PDF Views:144
Authors
Affiliations
1 Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, IN
2 Department of Medical Biotechnology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
1 Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, IN
2 Department of Medical Biotechnology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
Source
SMU Medical Journal, Vol 4, No 2 (2017), Pagination: 222-233Abstract
Effect of season on in vitro anti oxidant activity of Aageratum conyzoides Linn (A. conyzoides L.) leaves was studied. A. conyzoides L. leaves were collected in different seasons and its in vitro antioxidant activity was checked by superoxide anion generation with the help of xanthine-xanthine oxidase assay and with linoleic acid peroxidation assay as well as DPPH photometric assay. Total phenol, flavonoids, ascorbic acid and carotenoids contents of A. conyzoides L. leaves in different seasons were also estimated. Results showed that leaves of A. conyzoides L. of the month July and August had maximum in vitro anti oxidant activity. Anti oxidant activity was related with high content of total phenol, flavonoid and ascorbic acid in the leaves.Keywords
Ageratum conyzoides L. Leaves, Anti Oxidant Activity, Xanthine-Xanthine Oxidase Assay, Linoleic Acid Peroxidation Assay, DPPH Photometric Assay, Total Phenol, Flavonoids.Full Text
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- Isolation and Characterization of a Compound from the Leaves of Amaranthus spinosus Linn.
Abstract Views :472 |
PDF Views:151
Authors
Affiliations
1 Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, IN
2 Department of Medical Biotechnology, Sikkim Manipal University, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
3 Department of Biochemistry, Sikkim Manipal University, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
4 Department of Chemistry, University of North Bengal, Raja Rammohanpur 734430, Siliguri, West Bengal, IN
1 Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, IN
2 Department of Medical Biotechnology, Sikkim Manipal University, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
3 Department of Biochemistry, Sikkim Manipal University, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, IN
4 Department of Chemistry, University of North Bengal, Raja Rammohanpur 734430, Siliguri, West Bengal, IN
Source
SMU Medical Journal, Vol 4, No 2 (2017), Pagination: 259-268Abstract
By solvent extraction, acid hydrolysis, chromatography followed by crystallization, a compound was isolated from the leaves of Amaranthus spinosus Linn. Infra red spectroscopy, mass spectroscopy and nuclear magnetic resonance studies showed that the isolated compound was chemically 3,4 dihydroxy benzoic acid.Keywords
Amaranthus spinosus Linn., Chromatographic Techniques, 3,4 Dihydroxy Benzoic Acid.Full Text
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