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Viscometric, Volumetric and Acoustical Studies of N, N-Dimethylimidodicarbonirnidic Diamide Hydrochloride in Both Aqueous and Non-Aqueous Media at 303.15K


Affiliations
1 Department of Physics, Govt. Engg. College, Thirunelveli-627007, Tamil Nadu, India
2 Department of Physics, P.S.R. Engg. College, Sivakasi, India
 

N, N-Dimethylimidodicarbonimidic Diamide Hydrochloride (Metformin hydrochloride) has been widely used for management of non-insulin dependent diabetes mellitus. In this paper we present the result of ultra sonic velocity, density, viscosity of aqueous metformin hydrochloride solution and methanol-metformin hydrochloride solution for different concentration at T=303.15K. The variations in ultrasonic velocity and internal pressure play a significant role in understanding the solute-solvent, intra and inter molecular interactions. Further the acoustical relaxation time, acoustical impedance, internal pressure, free volume, enthalpy, inter molecular free length, Rao's constant, Wada's constant are computed. Hydrogen bonding and molecular interaction in the solutions are analyzed on the basis of viscometric, volumetric and acoustical data.
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  • Viscometric, Volumetric and Acoustical Studies of N, N-Dimethylimidodicarbonirnidic Diamide Hydrochloride in Both Aqueous and Non-Aqueous Media at 303.15K

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Authors

K. Rajagopal
Department of Physics, Govt. Engg. College, Thirunelveli-627007, Tamil Nadu, India
S. S. Jayabalakrishnan
Department of Physics, P.S.R. Engg. College, Sivakasi, India

Abstract


N, N-Dimethylimidodicarbonimidic Diamide Hydrochloride (Metformin hydrochloride) has been widely used for management of non-insulin dependent diabetes mellitus. In this paper we present the result of ultra sonic velocity, density, viscosity of aqueous metformin hydrochloride solution and methanol-metformin hydrochloride solution for different concentration at T=303.15K. The variations in ultrasonic velocity and internal pressure play a significant role in understanding the solute-solvent, intra and inter molecular interactions. Further the acoustical relaxation time, acoustical impedance, internal pressure, free volume, enthalpy, inter molecular free length, Rao's constant, Wada's constant are computed. Hydrogen bonding and molecular interaction in the solutions are analyzed on the basis of viscometric, volumetric and acoustical data.