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Evaluation of Antimycobacterial Activity of Curcuma xanthorrhiza Ethanolic Extract against Mycobacterium tuberculosis H37Rv in vitro


Affiliations
1 Study Program of Environmental Health, Polytechnic of Health, Surabaya, Indonesia
2 Department of Pharmacology, Wijaya Kusuma University, Surabaya, Indonesia
3 Department of Pharmacology, Airlangga University, Surabaya, Indonesia
 

Aim: The aim of this study was to evaluate the antimycobacterial activity of the Curcuma xanthorrhiza ethanolic extract in vitro.

Materials and Methods: Ethanolic extract of C. xanthorrhiza was set by maceration method. The broth microdilution and disc diffusion method were used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), respectively, of C. xanthorrhiza ethanol extract on strain Mycobacterium tuberculosis H37Rv.

Results: C. xanthorrhiza ethanol extract was found to have the antimycobacterial effects with a MIC value of 1600 μg/ml while MBC value of 3200 μg/ml for M. tuberculosis H37Rv.

Conclusion: From these findings , it can be concluded that C. xanthorrhiza ethanol extract have an antibacterial activity against Mycobacterium tuberculosis H37Rv in vitro and its potency elevated by increasing the C. xanthorrhiza ethanol extract concentration.


Keywords

Antimycobacterial, Curcuma xanthorrhiza, Minimal Bactericidal Concentration, Minimal Inhibitory Concentration.
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  • Evaluation of Antimycobacterial Activity of Curcuma xanthorrhiza Ethanolic Extract against Mycobacterium tuberculosis H37Rv in vitro

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Authors

Ngadino
Study Program of Environmental Health, Polytechnic of Health, Surabaya, Indonesia
Setiawan
Study Program of Environmental Health, Polytechnic of Health, Surabaya, Indonesia
Koerniasari
Study Program of Environmental Health, Polytechnic of Health, Surabaya, Indonesia
Ernawati
Department of Pharmacology, Wijaya Kusuma University, Surabaya, Indonesia
S. A. Sudjarwo
Department of Pharmacology, Airlangga University, Surabaya, Indonesia

Abstract


Aim: The aim of this study was to evaluate the antimycobacterial activity of the Curcuma xanthorrhiza ethanolic extract in vitro.

Materials and Methods: Ethanolic extract of C. xanthorrhiza was set by maceration method. The broth microdilution and disc diffusion method were used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), respectively, of C. xanthorrhiza ethanol extract on strain Mycobacterium tuberculosis H37Rv.

Results: C. xanthorrhiza ethanol extract was found to have the antimycobacterial effects with a MIC value of 1600 μg/ml while MBC value of 3200 μg/ml for M. tuberculosis H37Rv.

Conclusion: From these findings , it can be concluded that C. xanthorrhiza ethanol extract have an antibacterial activity against Mycobacterium tuberculosis H37Rv in vitro and its potency elevated by increasing the C. xanthorrhiza ethanol extract concentration.


Keywords


Antimycobacterial, Curcuma xanthorrhiza, Minimal Bactericidal Concentration, Minimal Inhibitory Concentration.