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Adah, A. S.
- Use of Goat Interleukin-6, Cortisol, and Some Biomarkers to Evaluate Clinical Suitability of Two Routes of Ascorbic Acid Administration in Transportation Stress
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Materials and Methods: Twenty-four apparently healthy Kalahari goats were grouped into four groups (A, B, C, and D) of 6 animals each: Group A-untreated and unexposed to stress; Group B-treated with 200 mg/kg Vitamin C orally and exposed to 2 h transportation stress; Group C-treated with Vitamin C 200 mg/kg intramuscularly and exposed to 2 h transportation stress; and Group D-untreated and exposed to 2 h transportation stress. The animals were stocked using standards stipulated by the Nigerian Animal Disease Control Act and transported at 40 km/h. Cortisol and interleukin-6 (IL-6) were assayed using quantitative sandwich ELISA. Classical stress hematological parameters and antioxidative stress markers such as glutathione s-transferase, superoxide dismutase, and malondialdehyde were determined. Heart rate variability (HRV) was also assessed.
Results: The route of ascorbic acid administration did not influence the expression of IL-6, and changes in cortisol surge, antioxidative stress markers, and other hematological parameters in Kalahari goats though Group C goats showed higher HRV values (p<0.05) than others. This gives credence to the enhanced cardiac responsiveness and stress survivability in Kalahari goats.
Conclusion: Both routes could be used in the administration of ascorbic acid. Kalahari goats exposed to short-term stress; however, the intramuscular route had better heart variability and thus improved the survivability of the animals.
Authors
Affiliations
1 Department of Veterinary Pharmacology and Toxicology, University of Ilorin, NG
2 Department of Veterinary Medicine, University of Ibadan, NG
3 Department of Veterinary Microbiology, University of Ilorin, NG
4 Institute of Food Security, Environmental Resources and Agricultural Research, IFSERAR, Federal University of Agriculture, Abeokuta, NG
5 Department of Veterinary Physiology and Biochemistry, University of Ilorin, NG
1 Department of Veterinary Pharmacology and Toxicology, University of Ilorin, NG
2 Department of Veterinary Medicine, University of Ibadan, NG
3 Department of Veterinary Microbiology, University of Ilorin, NG
4 Institute of Food Security, Environmental Resources and Agricultural Research, IFSERAR, Federal University of Agriculture, Abeokuta, NG
5 Department of Veterinary Physiology and Biochemistry, University of Ilorin, NG
Source
Veterinary World, Vol 11, No 5 (2018), Pagination: 674-680Abstract
Aim: The study determined the effect of ascorbic acid (administered orally and intramuscularly) in short-term transportation stress.Materials and Methods: Twenty-four apparently healthy Kalahari goats were grouped into four groups (A, B, C, and D) of 6 animals each: Group A-untreated and unexposed to stress; Group B-treated with 200 mg/kg Vitamin C orally and exposed to 2 h transportation stress; Group C-treated with Vitamin C 200 mg/kg intramuscularly and exposed to 2 h transportation stress; and Group D-untreated and exposed to 2 h transportation stress. The animals were stocked using standards stipulated by the Nigerian Animal Disease Control Act and transported at 40 km/h. Cortisol and interleukin-6 (IL-6) were assayed using quantitative sandwich ELISA. Classical stress hematological parameters and antioxidative stress markers such as glutathione s-transferase, superoxide dismutase, and malondialdehyde were determined. Heart rate variability (HRV) was also assessed.
Results: The route of ascorbic acid administration did not influence the expression of IL-6, and changes in cortisol surge, antioxidative stress markers, and other hematological parameters in Kalahari goats though Group C goats showed higher HRV values (p<0.05) than others. This gives credence to the enhanced cardiac responsiveness and stress survivability in Kalahari goats.
Conclusion: Both routes could be used in the administration of ascorbic acid. Kalahari goats exposed to short-term stress; however, the intramuscular route had better heart variability and thus improved the survivability of the animals.
Keywords
Ascorbic Acid, Intramuscular, Oral, Kalahari Goats, Stress.Full Text
References
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