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Biobaku, K. T.
- Use of Goat Interleukin-6, Cortisol, and Some Biomarkers to Evaluate Clinical Suitability of Two Routes of Ascorbic Acid Administration in Transportation Stress
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Materials and Methods: Twenty-four apparently healthy Kalahari goats were grouped into four groups (A, B, C, and D) of 6 animals each: Group A-untreated and unexposed to stress; Group B-treated with 200 mg/kg Vitamin C orally and exposed to 2 h transportation stress; Group C-treated with Vitamin C 200 mg/kg intramuscularly and exposed to 2 h transportation stress; and Group D-untreated and exposed to 2 h transportation stress. The animals were stocked using standards stipulated by the Nigerian Animal Disease Control Act and transported at 40 km/h. Cortisol and interleukin-6 (IL-6) were assayed using quantitative sandwich ELISA. Classical stress hematological parameters and antioxidative stress markers such as glutathione s-transferase, superoxide dismutase, and malondialdehyde were determined. Heart rate variability (HRV) was also assessed.
Results: The route of ascorbic acid administration did not influence the expression of IL-6, and changes in cortisol surge, antioxidative stress markers, and other hematological parameters in Kalahari goats though Group C goats showed higher HRV values (p<0.05) than others. This gives credence to the enhanced cardiac responsiveness and stress survivability in Kalahari goats.
Conclusion: Both routes could be used in the administration of ascorbic acid. Kalahari goats exposed to short-term stress; however, the intramuscular route had better heart variability and thus improved the survivability of the animals.
Authors
Affiliations
1 Department of Veterinary Pharmacology and Toxicology, University of Ilorin, NG
2 Department of Veterinary Medicine, University of Ibadan, NG
3 Department of Veterinary Microbiology, University of Ilorin, NG
4 Institute of Food Security, Environmental Resources and Agricultural Research, IFSERAR, Federal University of Agriculture, Abeokuta, NG
5 Department of Veterinary Physiology and Biochemistry, University of Ilorin, NG
1 Department of Veterinary Pharmacology and Toxicology, University of Ilorin, NG
2 Department of Veterinary Medicine, University of Ibadan, NG
3 Department of Veterinary Microbiology, University of Ilorin, NG
4 Institute of Food Security, Environmental Resources and Agricultural Research, IFSERAR, Federal University of Agriculture, Abeokuta, NG
5 Department of Veterinary Physiology and Biochemistry, University of Ilorin, NG
Source
Veterinary World, Vol 11, No 5 (2018), Pagination: 674-680Abstract
Aim: The study determined the effect of ascorbic acid (administered orally and intramuscularly) in short-term transportation stress.Materials and Methods: Twenty-four apparently healthy Kalahari goats were grouped into four groups (A, B, C, and D) of 6 animals each: Group A-untreated and unexposed to stress; Group B-treated with 200 mg/kg Vitamin C orally and exposed to 2 h transportation stress; Group C-treated with Vitamin C 200 mg/kg intramuscularly and exposed to 2 h transportation stress; and Group D-untreated and exposed to 2 h transportation stress. The animals were stocked using standards stipulated by the Nigerian Animal Disease Control Act and transported at 40 km/h. Cortisol and interleukin-6 (IL-6) were assayed using quantitative sandwich ELISA. Classical stress hematological parameters and antioxidative stress markers such as glutathione s-transferase, superoxide dismutase, and malondialdehyde were determined. Heart rate variability (HRV) was also assessed.
Results: The route of ascorbic acid administration did not influence the expression of IL-6, and changes in cortisol surge, antioxidative stress markers, and other hematological parameters in Kalahari goats though Group C goats showed higher HRV values (p<0.05) than others. This gives credence to the enhanced cardiac responsiveness and stress survivability in Kalahari goats.
Conclusion: Both routes could be used in the administration of ascorbic acid. Kalahari goats exposed to short-term stress; however, the intramuscular route had better heart variability and thus improved the survivability of the animals.
Keywords
Ascorbic Acid, Intramuscular, Oral, Kalahari Goats, Stress.Full Text
References
- Tanko, P.N., Opeyemi, O.M., Sabri, M.Y., Siti-Khairani, B., Shahrom, S. and Effendy, A.W.M. (2014) The ameliorative effect of ascorbic acid on the oxidative status, live weight and recovery rate in road transport stressed goats in a hot humid tropical environment. Anim. Sci. J., 85: 611-616.
- Nawito, M.F., Amal, R., El Hameed, A.S.A., Sosa, A. and Karima, G. M. (2016) Impact of pregnancy and nutrition on oxidant⁄antioxidant balance in sheep and goats reared in South Sinai, Egypt. Vet. World, 9: 801-805.
- Hsiang, L.C., John, L.K. (2016) Differential effects of roads and traffic on space use and movements of native forest dependent and introduced edge-tolerant species. PLoS One, 11: e0148121.
- Bender, D.A. (2003) Nutritional Biochemistry of the Vitamins. 2nd ed. Cambridge University Press, Cambridge. p445.
- Sivakumar, A.V.N., Singh, G. and Varshney, V.P. (2010), Antioxidants supplementation on acid-base balance during heat stress in goats. Asian Aust. J. Anim. Sci., 23: 1462-1468.
- Adenkola, A.Y., Ayo, J.O., Sackey, A.K.B. and Adelaiye, A.B. (2011) Eight hours road transportation and ascorbic acid administration effects on haematological parameters of pigs during the harmattan season. Agric. Biol. J. N. Am., 2: 1143-1150.
- Biobaku, K.T., Okediran, B.S., Adebiyi, A.T., Aremu, A. and Atata, A.J. (2017) Evaluating the anti-stress potential of propofol in road transportation welfare using bio-markers in West African Dwarf Goats. Bangladesh J. Vet. Med., 14: 171-177.
- Adenkola, Y.A., Ayo. J.O., Sackey, A.K.B., Adelaiye, A.B. and Minka, N.S. (2009) Excitability Scores of pigs administered ascorbic acid and transported during harmattan season. Vet. Arhiv., 79: 471-480.
- Adeyemi, I.G., Adeyemo, O.K. and Alli, O.A. (2010) Economic loss from transportation stress in slaughter cattle: The case of akinyele cattle market, Nigeria. Bull. Anim. Hlth. Prod. Afric., 58: 89-94.
- Biobaku, K.T., Agaie, B.M. and Aremu, A. (2017) Evaluating stress amelioration of oral vitamin C in bucks exposed to long-term road transportation and stocking. Bangladesh J. Vet. Med., 15: 33-38.
- Ayo, J.O., Minka, N.S. and Mamman, M. (2006) Excitability scores of goats administered ascorbic acid and transported during hot-dry conditions. J. Vet. Sci., 7: 127-131.
- Fayomi, A., Ayo, J.O., Akinpelu, A.O. and Nwanta, J.A. (2006) Effects of ascorbic acid on diurnal variation in rectal temperature of pigs during the hot-dry season. Nig. Vet. J., 30: 85-88.
- Khalid, T.B., Jibir, M., Ismail, A.O., Onifade, K.I., Ismaila, M.S. and Agaie, B.M. (2016) Ascorbic acid supplementation improves the quality of meat characteristics in sahel bucks exposed to long-distance road transport. Alex. J. Vet. Sci., 51: 87-94.
- Ayo, J.O., Minka, N.S., Sackey, A.K.B. and Adelaiye, A.B. (2009) Responses of serum electrolytes of goats to twelve hours of road transportation during the hot-dry season in Nigeria, and the effects of pretreatment with ascorbic acid. Onderstepoort. J. Vet. Res., 78: 409-419.
- Borell, V.E., Langbein, J., Despres, G., Hansen, S., Leterrier, C., Marchant-Forde, J., Marchant-Forde, R., Minero, M., Mohar, E., Prunier, A., Valance, D. and Veissier, I. (2007) Heart rate variability as a measure of autonomic regulation of cardiac activity for assessing stress and welfare in farm animals-a review. Physiol. Beha., 92: 293-316.
- Reddy, S.B., Venkatasivakumar, R., Sivajothi, S. and Reddy, Y.V.P. (2014) Electrocardiographic abnormalities in young healthy Sheep and goats. Int. J. Biol. Res., 2: 21-22.
- Jain, N.C.S. (1986), Veterinary Hematology. 4th ed. Lea and Fibiger, Philadelphia.
- Chauhan, R.S. and Agarwal, D.K. (2006) Veterinary Clinical and Laboratory Diagnosis. 2nd ed. Jaypee Publishers, India.
- Ajadi, R.A., Kehinde, O.O., Sonibare, A.O., Gazal, O.S. and Kasali, O.B. (2012) Effects of road transportation of cattle between transboundary area and central abattoir of Abeokuta, Ogun State on Plasma cortisol, blood glucose and leukocyte parameters. Bull. Anim. Hlth. Prod., 60: 373-376.
- Chulayo, A.Y. and Muchenje, V. (2013) The effects of pre-slaughter stress and season on the activity of plasma creatine kinase and mutton quality from different sheep breeds slaughtered at a smallholder abattoir. Asian Aust. J. Anim. Sci., 26(12): 1762-1772.
- Zhou, D., Kusnecophv, A.W., Shurin, M.R., Depaoli, M. and Rabin, B.S. (1993) Exposure to physical and psychological stressors alleviates plasma interleukin-6: Relationship to physical and psychological to activation of hypothalamicpituitary-adrenal axis. Endocrinology, 133: 2523-2530.
- Kotze, A., Swart, H., Grobler, J.P. and Nemaangani, A. (2004) A genetic profile of the Kalahari Red goat breed from Southern Africa. South Afri. J. An. Sci., 34: 12-15.
- Adenkola, A.Y. and Okoro, L.I. (2014) Serum malondialdehyde concentration, rectal temperature and excitability score in road transported rams administered with Vitamin C +E combination and vitamin C. Nig. Vet. J., 32: 995-1006.
- Ahmed, M.W., Kadish, A.H., Paker, M.A. and Goldberger, J.J. (1994) Effects of physiological and pharmacological adrenergic-stimulation on heart-rate variability. J. Am. Coll. Cardiol., 24: 1082-1090.
- Jokkel, G., Bonyhay, I. and Kollai, M. (1995) Heart-rate variability after complete autonomic blockade in man. J. Auto. Nerv. Syst., 51: 85-89.
- Asghar, M., George, L. and Lokhandwala, M.F. (2007) Exercise decreases oxidative stress and Inflammation and restores renal dopamine D receptor function in rats. Am. J. Physiol. Renal Physiol., 293: 914-919.