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Authors
Affiliations
1 Department of Zoonotic Diseases, National Research Centre, Dokki, Giza, EG
2 Department of Parasitology and Animal Diseases, National Research Centre, Dokki, Giza, EG
Source
Veterinary World, Vol 11, No 2 (2018), Pagination: 215-220
Abstract
Background: Fasciolosis is an important zoonotic disease affecting the productive performance of farm animals in Egypt.
Aim: The aim of the present study was comparing the ovicidal effect of different extracts as an alcoholic (Methanolic and Ethanolic) and aqueous Moringa oleifera leaf extracts on Fasciola gigantica non-embryonated and developed eggs.
Materials and Methods: Tested concentrations of extracts ranged from 12.5 to 800 mg/ml. Nitroxynil was used as reference drug with a dose of 100 mg/ml.
Results: M. oleifera alcoholic and aqueous extracts showed a concentration-dependent ovicidal effect on F. gigantica non-embryonated and developed eggs. Based on LC50 values, water extract showed the highest ovicidal activity since it registered the lowest values of 2.6 mg/ml on non-embryonated eggs. Non-embryonated eggs were more susceptible to aqueous extract than developed eggs. On the other hand, the developed eggs were more susceptible to ethanolic extract than non-embryonated eggs even the lowest LC50 (12.38 mg/ml).
Conclusion: M. oleifera leaf extracts especially aqueous extract could be a promising step in the field of controlling fascioliasis. Further, in vivo studies are needed to enlighten the therapeutic potential of M. oleifera extracts in treating F. gigantica infection.
Keywords
Fasciola gigantica, Leaf Extract, Moringa oleifera, Nitroxynil, Ovicidal Activity.
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