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Abdullah, Rasedee
- Therapeutic Uses of Epicatechin in Diabetes and Cancer
Abstract Views :107 |
PDF Views:0
Authors
Layth Abdulmajeed Abdulkhaleq
1,
Mohammed Abdulrazzaq Assi
2,
Mohd Hezmee Mohd Noor
2,
Rasedee Abdullah
1,
Mohd Zamri Saad
1,
Yun Hin Taufiq-Yap
3
Affiliations
1 Department of Veterinary Laboratory Diagnostics, Universiti Putra Malaysia, Serdang-43400, Selangor, MY
2 Department of Veterinary Preclinical Sciences, Universiti Putra Malaysia, Serdang-43400, Selangor, MY
3 Department of Chemistry, Universiti Putra Malaysia, Serdang-43400, Selangor, MY
1 Department of Veterinary Laboratory Diagnostics, Universiti Putra Malaysia, Serdang-43400, Selangor, MY
2 Department of Veterinary Preclinical Sciences, Universiti Putra Malaysia, Serdang-43400, Selangor, MY
3 Department of Chemistry, Universiti Putra Malaysia, Serdang-43400, Selangor, MY
Source
Veterinary World, Vol 10, No 8 (2017), Pagination: 869-872Abstract
Epicatechin is a natural flavonoid found in green tea. It has been reported to possess an immense antioxidant effect which contributes to its therapeutic effect against a handful of ailments. In this review, we discuss its therapeutic role in the management of two of the most important human diseases; diabetes and cancer. The consumption of epicatechin has been shown to reduce blood glucose levels in diabetic patients, while is anticancer effect was attributed to its antioxidant properties, antiangiogenic and direct cytotoxicity to cancer cells. Although the exact mechanism of action of epicatechin is still being explored, there is no doubt that it is a promising candidate as an alternative. The significance of this review is to highlight the importance of the usage of natural products (in this case, epicatechin) as an alternative for the treatment of two potentially fatal diseases which is diabetes and cancer. The aim of this review is to educate the scientific community on the role of epicatechin in ameliorating the effects of diabetes and cancers on human while understanding the potential mechanisms of these aforementioned effects.Keywords
Angiogenesis, Carcinoma, Diabetes Mellitus, Epicatechin, Oxidative Stress.Full Text
- The Crucial Roles of Inflammatory Mediators in Inflammation:A Review
Abstract Views :181 |
PDF Views:0
Authors
L. A. Abdulkhaleq
1,
M. A. Assi
2,
Rasedee Abdullah
3,
M. Zamri-Saad
3,
Y. H. Taufiq-Yap
4,
M. N. M. Hezmee
5
Affiliations
1 Department of Pathology and Poultry Diseases, Baghdad University, Baghdad, IQ
2 Department of Community Health, College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, IQ
3 Department of Veterinary Laboratory Diagnostics, Universiti Putra Malaysia, MY
4 Department of Chemistry, Universiti Putra Malaysia, MY
5 Department of Veterinary Preclinical Sciences, Universiti Putra Malaysia, MY
1 Department of Pathology and Poultry Diseases, Baghdad University, Baghdad, IQ
2 Department of Community Health, College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, IQ
3 Department of Veterinary Laboratory Diagnostics, Universiti Putra Malaysia, MY
4 Department of Chemistry, Universiti Putra Malaysia, MY
5 Department of Veterinary Preclinical Sciences, Universiti Putra Malaysia, MY
Source
Veterinary World, Vol 11, No 5 (2018), Pagination: 627-635Abstract
The inflammatory response is a crucial aspect of the tissues’ responses to deleterious inflammogens. This complex response involves leukocytes cells such as macrophages, neutrophils, and lymphocytes, also known as inflammatory cells. In response to the inflammatory process, these cells release specialized substances which include vasoactive amines and peptides, eicosanoids, proinflammatory cytokines, and acute-phase proteins, which mediate the inflammatory process by preventing further tissue damage and ultimately resulting in healing and restoration of tissue function. This review discusses the role of the inflammatory cells as well as their by-products in the mediation of inflammatory process. A brief insight into the role of natural anti-inflammatory agents is also discussed. The significance of this study is to explore further and understand the potential mechanism of inflammatory processes to take full advantage of vast and advanced anti-inflammatory therapies. This review aimed to reemphasize the importance on the knowledge of inflammatory processes with the addition of newest and current issues pertaining to this phenomenon.Keywords
Chemokines, Cytokines, Inflammatory Mediators, Inflammatory Response.Full Text
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