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Ozair, Ahmad
- The Effect of Clonidine on Peri-Operative Neuromuscular Blockade and Functional Recovery: A Randomized Placebo-Controlled Trial
Authors
1 Department of Anaesthesiology, Integral Institute of Medical Sciences and Research, Lucknow, Uttar Pradesh, IN
2 King George's Medical University (KGMU), Lucknow, Uttar Pradesh, IN
3 Department of Anaesthesiology and Critical Care, J.N. Medical College, AMU, Aligarh, Uttar Pradesh, IN
Source
Central Journal of ISA, Vol 2, No 2 (2018), Pagination: 44-51Abstract
Background: Alpha-2-agonists are as used adjunct for anaesthesia. We conducted this study with the aim to determine whether the addition of clonidine, an α-2-agonist, decreases the time to recovery from neuromuscular blockade caused by non-depolarising muscle relaxant. Secondary objectives were to know whether clonidine as an adjuvant improves hemodynamic stability, decreases stress hyperglycaemia, pain and time to discharge from Post-Anaesthesia Care Unit (PACU).
Methods: This placebo-controlled clinical trial, enrolled 64 patients into clonidine (n = 32) or placebo (saline) group (n = 32). Study drug was given 1.5 mcg/kg IV bolus at the time of induction followed by infusion (1.5 mcg/kg/hour) intra-operatively. Extubation was started when train-of-four (TOF) count was ≥ 2. Primary outcome measure was time to achieve TOF ratio of ≥ 70% and ≥ 90%, assessed at 5, 15, 30- and 60-min intervals following extubation.
Results: 2 patients in each group were excluded due to intra-operative requirement of additional supportive medications, hence in each group 30 were analysed. Significant difference was observed between clonidine and placebo groups in terms of time to achieve TOF ratio ≥ 70% and ≥ 90%, stress hyperglycemia, hemodynamic and pain profile, no statistical difference in the Ramsey sedation score and modified Aldrete score between groups. Patients given clonidine required repeat doses of non-depolarising muscle relaxant at longer intervals, with decrease in total amount administered. Clonidine group had a median time to achieve TOF ratio ≥ 70% at 15 min compared to 60 min in placebo group.
Conclusion: Clonidine hastens the recovery from neuromuscular block with reduced stress hyperglycaemia and post-operative pain, along with unaffected Ramsey sedation score and modified Aldrete score.
Keywords
Clonidine and Neuromuscular Recovery, Clonidine and Functional Recovery.Full Text
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