Design and In Vitro Evaluation of Nimesulide Loaded Solid Lipid Nanoparticles (SLN's)

Purpose: The purpose of present investigation was to prepare solid lipid nanoparticles of Nimesulide (NSL) and to evaluate and characterize the prepared optimum formulation.

Methods: This technique was selected on the basis of production yield, ease of formulation and practicability. For improving oral bioavailability, Nimesulide loaded SLNs were developed using glyceryl monostearate was the best lipid for NSL SLNs. Polyvinyl alcohol was used as surfactant. SLNs were characterized for particle size, entrapment efficiency, drug loading, In-vitro drug release measurements for the analysis of polymorphic modifications.

Results: Particle size of SLNs was measured by Malvern Zetasizer and under Projection Microscope and was found to be in the limit of 300-500 nm and also had almost round and uniform shape. In-vitro release studies showed that Nimesulide (NSL) was released from SLNs in a sustained manner for all formulations.

Conclusions: Thus, it can be concluded that a systematic formulation approach can be adopted to reach an optimum point in the shortest time with minimum efforts.