FoodSci: Indian Journal of Research in Food Science and Nutrition

Open Access Open Access  Restricted Access Subscription Access

Assessment of Genotoxicity of Cassia auriculata Flower Powder


Affiliations
1 Department of Biomedical Engineering, Velalar College of Engineering and Technology, Erode – 638012, India
 

The flower of Cassia auriculata commonly used for treatment, especially in Ayurvedic medicine in India was tested for mutagenicity by the Ames test using Salmonella typhimurium TA 98, TA 100 and TA 102 strains. The genotoxicity assessment of flower powder of Cassia auriculata was performed in aqueous extract 1:10. The flower powder of Cassia auriculata did not induce any frame shift mutation in the strain TA 98, which indicates its antimutagenic effect and did not cause any base pair substitution at the dose level tested 100μg/plate. The colony counts in all the three strains were found close to the spontaneous revertants frequency showing that flower powder of Cassia auriculata is antimutagenic at the dose level tested (100μg/plate).

Keywords

Aqueous Extract, Cassia auriculata, Mutagenicity, Salmonella typhimurium.
User
Notifications
Font Size


  • Bhavapriya V, Kalpana S, Govindasamy S, Apparanantham. T Biochemical studies on hypoglycemic effect of Aavarai kudineer, A Herbal formulation in alloxan diabetics rats, Indian journal of experimental biology. 2001; 39:925–8. PMid:11831378

  • Kelber O, Steinhoff B, Kraft K. Assessment of genotoxicity of herbal medicinal products: A co-ordinated approach. Phytomedicine. 2012; 19(5):472–6. https://doi.org/10.1016/j.phymed.2011.11.008 PMid: 22301069

  • European Medicines Agency (2008) Guidelines on Human Cell Waste Medicinal products; 2008. EMEA/CHMP 410869/2006


Abstract Views: 733

PDF Views: 424




  • Assessment of Genotoxicity of Cassia auriculata Flower Powder

Abstract Views: 733  |  PDF Views: 424

Authors

N. Jeyashanthi
Department of Biomedical Engineering, Velalar College of Engineering and Technology, Erode – 638012, India
P. Ravikumar
Department of Biomedical Engineering, Velalar College of Engineering and Technology, Erode – 638012, India
N. N. Baalakumar
Department of Biomedical Engineering, Velalar College of Engineering and Technology, Erode – 638012, India

Abstract


The flower of Cassia auriculata commonly used for treatment, especially in Ayurvedic medicine in India was tested for mutagenicity by the Ames test using Salmonella typhimurium TA 98, TA 100 and TA 102 strains. The genotoxicity assessment of flower powder of Cassia auriculata was performed in aqueous extract 1:10. The flower powder of Cassia auriculata did not induce any frame shift mutation in the strain TA 98, which indicates its antimutagenic effect and did not cause any base pair substitution at the dose level tested 100μg/plate. The colony counts in all the three strains were found close to the spontaneous revertants frequency showing that flower powder of Cassia auriculata is antimutagenic at the dose level tested (100μg/plate).

Keywords


Aqueous Extract, Cassia auriculata, Mutagenicity, Salmonella typhimurium.

References





DOI: https://doi.org/10.15613/fijrfn%2F2017%2Fv4i2%2F167615