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Thermal and structural characterization of a new surfactant based on 4-hydroxycoumarin by Differential Scanning Calorimeter (DSC) and Polarizing Optical Microscope (POM)
In this study, we synthesized new substituted coumarins, with the structure confirmed using 1H nuclear magnetic resonance. Differential Scanning Calorimetry (DSC) and Polarizing Optical Microscope (POM) analysis were used to monitor the thermal behavior of the coumarin and its mixtures. DSC revealed a unique glass transition temperature for the first two products, the glass transition temperature of the third could not be determined.The variation in molecule density increases or decreases with increasing temperature, this was detected by the MOP. We see for instance small aggregates with a phase change that occurs between 25°C and 40°C, this phenomenon results in the formation of (micelles).This study is different from the others available because telomers using heterocycles are the speciality of our laboratory, several routes have been set to improve their synthesis and in particular the coumarin series.The latter are analogues of active substances. For example, thiophene series analogues of paullones have been evaluated on MCF-7 breast cancer cells.For Alzheimer's disease, the synthesis of numerous analogues of Tacrine, used as a treatment, have been carried out and the activities have been tested. Similarly, coumarin analogues have been evaluated for ROS (reactive oxygen species) reduction and phosphatase inhibition.
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