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The Participation of Cell Adhesion Molecules in Cancer Progression: a Recent Review


Affiliations
1 Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore – 641114, Tamil Nadu, India
 

Cell Adhesion Molecules (CAMs) are proteins found on the surface of the cell and are responsible for binding to components of the extra cellular matrix or to receptors on other cells. CAMs are highly essential for cell proliferation, and differentiation, as well as migration. There are four important families of CAMs, namely Integrins, Cadherins, Selectins and the Immunoglobulin Super family (IgSF). Integrins are involved in the metastasis of cancer cells and angiogenesis. Selectins are vital to inflammation and the progression of cancer. Cadherins play a prominent role in tumor growth. Members of the IgSF are involved in the inflammation process. CAMs play critical roles in the progression of cancer. Novel approaches can be developed using a combination of cytotoxic and Heparin-based drugs to treat malignant tumors.

Keywords

Cell Adhesion Molecules, Integrins, Selectins, Cadherins, Immunoglobulin Superfamily, Metastasis
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  • Andrews, J. L., Kim, A. C., & Hens, J. R. (2012, February 8). The role and function of cadherins in the mammary gland. Breast Cancer Research, 14(1), 203-213.

  • Barthel, S., Gavino, J., Descheny, L., & Dimitroff, C. (2007). Targeting selectins and selectin ligands in inflammation and cancer. Expert Opinion on Therapeutic Targets, 11(11), 1473–1491.

  • Bendas, G., & Borsig, L. (2012). Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparin. International Journal of Cell Biology, 1-10.

  • Borsig, L., Wong, R., Hynes, R., Vark, N., & Vark, A. (2002). Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proceedings of the National Acadamey of Sciences U.S.A., 99(4), 2193-2198.

  • Brooks, P. C., Clark, R. A., & Cheresh, D. A. (1994). Requirement of vascular integrin a(v)ß3 for angiogenesis. Science, 264(5158), 569-574.

  • Christofori, G., & Semb, H. (1999, February). The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends in Biochemical Sciences, 24(2), 73-76.

  • Cotran, R., & Kumar, V. (1994). Inflammation and repair. In R. Cotran, V. Kumar, S. Robbins, & F. Schoen (Eds.), Robbins Pathologic Basis of Disease (pp. 51–93). Philadelphia: WB Saunders Company.

  • Desgrosellier, J., & Cheresh, D. (2010). Integrins in cancer: biological implications and therapeutic opportunities. Nature Reviews Cancer, 10(1), 9-22.

  • Gupta, G., & Massagu´e, J. (2006). Cancer metastasis: building a framework. Cell, 127(4), 679-695.

  • Hill, C. (2012). Interactions between endothelial selectins and cancer cells regulate metastasis. Frontiers in Bioscience, 17, 3233–3251.

  • Johnson, J. P. (1999). Cell adhesion molecules in the development and progression of malignant melanoma. Cancer and Metastasis Reviews, 18(3), 345-357.

  • Ley, K. (2003). The role of selectins in inflammation and disease. Trends in Molecular Medicine, 9, 263–268.

  • Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007). Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nature Reviews Immunology, 7(9), 678–689.

  • Lodish, H., Berk, A., Matsudaira, P., Kaiser, C., Krieger, M., Scott, M., et al. (2003). Molecular Cell Biology (5th ed.). W.H. Freeman Publishers.

  • Simmons, D. (1999). The immunoglobulin superfamily. In E. E. Bittar, D. R. Garrod, A. J. North, & M. A. Chidgey (Eds.), Advances in molecular and cell biology: The Adhesive Interactions of Cells (Vol. 28, pp. 113-132). JAI Press Inc.

  • Ulbrich, H., Eriksson, E. E., & Lindbom, L. (2003). Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease. Trends in Pharmacological Sciences, 24(12), 640-647.

  • Witz, I. (2006). Tumor-microenvironment interactions: the selectin-selectin ligand axis in tumor-endothelium cross talk. Cancer Treatment and Research, 130, 125-140.

  • Zhang, J., Nakayama, J., Ohyama, C., Suzuki, M., Suzuki, A., Fukuda, M., et al. (2002). Sialyl Lewis X-dependent lung colonization of B16 melanoma cells through a selectin-like endothelial receptor distinct from E- or P-selectin. Cancer Research, 62, 4194-4198.


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  • The Participation of Cell Adhesion Molecules in Cancer Progression: a Recent Review

Abstract Views: 475  |  PDF Views: 354

Authors

Sherlyn Jemimah
Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore – 641114, Tamil Nadu, India
Gincy George
Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore – 641114, Tamil Nadu, India
N. Sathyakiruba
Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore – 641114, Tamil Nadu, India
Sheeba Kosari
Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore – 641114, Tamil Nadu, India
Vandanaapurva Das
Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore – 641114, Tamil Nadu, India

Abstract


Cell Adhesion Molecules (CAMs) are proteins found on the surface of the cell and are responsible for binding to components of the extra cellular matrix or to receptors on other cells. CAMs are highly essential for cell proliferation, and differentiation, as well as migration. There are four important families of CAMs, namely Integrins, Cadherins, Selectins and the Immunoglobulin Super family (IgSF). Integrins are involved in the metastasis of cancer cells and angiogenesis. Selectins are vital to inflammation and the progression of cancer. Cadherins play a prominent role in tumor growth. Members of the IgSF are involved in the inflammation process. CAMs play critical roles in the progression of cancer. Novel approaches can be developed using a combination of cytotoxic and Heparin-based drugs to treat malignant tumors.

Keywords


Cell Adhesion Molecules, Integrins, Selectins, Cadherins, Immunoglobulin Superfamily, Metastasis

References