International Journal of Contemporary Medicine

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Study of Role of Tacrolimus in the Treatment of Lichen Planus


Affiliations
1 Dept of Oral Medicine and Radiology, Dr. D. Y Patil Dental College and Hospital, Navi Mumbai, Maharashtra, India
     

   Subscribe/Renew Journal


Oral lichen planus is a chronic inflammatory immunological reaction in which epidermal or epithelial basal cell damage produces mucocutaneous lesions of various types anticipated to occur in 0.5 to 1 % of adult individuals of the middle ages, consequential in mucosal ulceration and scarring. The basis of this study is to explore the usefulness of tacrolimus to treat the oral lesion of lichen planus. Consequently, in the present study we have included a group of patients having oral lichen planus, we intend to uncover a collateral therapy for oral lichen planus other than corticosteroids which has been the mainstay of treatment since their introduction decades ago.

Keywords

Lichen Planus, Tacrolimus, Immunomodulators.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Oliver GF, Winkelmann RK. Treatment of lichen planus. Drugs 1993;45:56–65.

  • Dusek J, Frick W. Lichen planus: oral manifestations and suggested treatments. J Oral Maxillofac Surg 1982;40:240–244.

  • Scully C, El-Kom M. Lichen planus: review and update on pathogenesis. J Oral Pathol 1985;14:431–458.

  • Cawson RA. Treatment of oral lichen planus with betamethasone. BMJ. 1968;ii:86–89.

  • Tyldesley WR, Harding SM. Betamethasone valerate aerosol in the treatment of oral lichen planus. Br J Dermatol 1977;96:659–662.

  • Greenspan JS, Yeoman CM, Harding SM. Oral lichen planus: a double-blind comparison of treatment with betamethasone valerate aerosol and pellets. Br Dent J 1978;144:83–84.

  • Zegarelli DJ, Kutscher A, Mehrhof A. Long standing lozenges with triamcinolone acetonide. NY Stat J Med 1969;69:2463–2466.

  • Rushton RJ. Treatment of ulcerative mouth lesions with orabase. Br J Dermatol 1962;74: 462–464.

  • Vincent SD, Fotos PG, Baker KA, Williams TP. Oral lichen planus: the clinical, historical and therapeutic features of 100 cases. Oral Surg Oral Med Oral Pathol 1990;70:165–171.

  • Aleinikov A, Jordan RCK, Main JHP. Topical steroid therapy in oral lichen planus: review of a novel delivery method in 24 patients. J Canad Dent Assoc 1996;62:324–327.

  • Lozada F, Silverman S. Topically applied fluocinonide in an adhesive base in the treatment of oral vesiculoerosive diseases. Arch Dermatol 1980;116:190–201.

  • Plemons JM, Rees TD, Zachariah NY. Absorption of topical steroid and evaluation of adrenal suppression in patients with erosive lichen planus. Oral Surg Oral Med Oral Pathol 1990;69:688–693.

  • Thongprasom K, Luangjarmekorn L, Sererat T, Taweesap W. Relative efficacy of fluocinolone acetonide compared with triamcinolone acetonide in treatment of oral lichen planus. J Oral Pathol Med 1992;21:456–458.

  • Voûte ABE, Schulten EAJM, Langendijk PNJ, Kostense PJ, van der Waal I. Fluocinonide in an adhesive base for treatment of oral lichen planus. Oral Surg Oral Med Oral Pathol 1993;75:181–185.

  • Lozada-Nur F, Huang MZ. Open preliminary clinical trial of clobetasol propionate ointment in adhesive paste for treatment of chronic oral vesiculoerosive diseases. Oral Surg Oral Med Oral Pathol 1991;71:283–287.

  • Lehner T, Lyne C. Adrenal function during topical oral corticosteroid treatment. BMJ 1969;iv: 138–141.

  • Beckman BI. Valisone aerosol spray contraindicated in mucous membranes. J Am Acad Dermatol 1981;4:233.

  • Silverman S, Gorsky M, Lozada-Nur F, Giannoti K. A prospective study of findings and management in 214 patients with oral lichen planus. Oral Surg Oral Med Oral Pathol 1991;72:665–670.

  • McCartan BE, Jontell M, Jungell P et al. Third European Congress of Oral Medicine. Oral Diseases 1997;3:43–48.

  • Sleeper HR. Intralesional and sublesional injection of triamcinolone acetonide for oral lichen planus. Yale J Biol Med 1967;40:164–165.

  • Randell J, Cohen L. Erosive lichen planus. Management of oral lesions with intralesional corticosteroid injections. J Oral Med 1974;29: 88–91.

  • Zegarelli DJ. Multimodality steroid therapy of erosive and ulcerative oral lichen planus. J Oral Med 1983;38:127–130.

  • Eisen D. The therapy of oral lichen planus. Crit Rev Oral Biol Med 1993;4:141–158.

  • Lozada F, Silverman S, Migliorati C. Adverse side effects associated with prednisone in the treatment of patients with oral inflammatory ulcerative diseases. J Am Dent Assoc 1984;1091:269–270.

  • Sehgal VN, Rege VL, Beohar PC. Use of griseofulvin. Arch Dermatol 1971;104:221.

  • Sehgal VN, Abraham GJS, Malik GB. Griseofulvin therapy in lichen planus – a double-blind controlled trial. Br J Dermatol 1972;87:383–385.

  • Sehgal VN, Bikhchandani R, Koranne RV, Nayar M, Saxena HM. Histopathological evaluation of griseofulvin therapy in lichen planus-a doubleblind controlled study. Dermatologica 1980;161:22–27.

  • Aufdemorte T, De Villez R, Giesecker D. Griseofulvin in the treatment of three cases of erosive lichen planus. Oral Surg Oral Med Oral Pathol 1983;55:459–462.

  • Levy A, Stempler D, Yuzuk S, Schewach-Millet M, Ronen M. Treatment of lichen planus with griseofulvin. Int J Dermatol 1986;25:405.

  • Bagan JV, Silvestre FJ, Mestre S, Gisbert C, Bermejo A, Agramunt J. Treatment of lichen planus with griseofulvin. Oral Surg Oral Med Oral Pathol 1985;60:608–610.

  • Naylor GD. Treating erosive lichen planus with griseofulvin.-a report of four cases. Quint Internat 1990;21:943–947.

  • Matthews RW, Scully C. Griseofulvin in the treatment of oral lichen planus: adverse drug reactions, but little beneficial effect. Ann Dent 1992;51:10–11.

  • Borel JF, Feurer C, Magnee C, Staehelin H. Effects of the new antilymphocytic peptide cyclosporin A in animals. Immunology 1977;32:1017–1025.

  • Pigatto PD, Chiappino A, Bigardi N, Mozzanica N, Finzi AF. Cyclosporin A for treatment of severe lichen planus. Br J Dermatol 1990;122:121–123.

  • Frances CS, Boisnic SE, Szpirglas H. Effect of the local application of cyclosporine A on chronic erosive lichen planus of the oral cavity. Dermatologica 1988;177:194–195.

  • Balato N, De Rosa S, Bordone S, Ayala F. Dermatological application of cyclosporine. Arch Dermatol 1989;125:1430–1431.

  • Eisen D, Ellis CN, Duell EA, Griffiths CE, Voorhees JJ. Effect of topical cyclosporine rinse on oral lichen planus: a double-blind analysis. N Engl J Med 1990;323:290–294.

  • Higgins EM, Munro CS, Friedman PS. Cyclosporin A in the treatment of lichen planus. Arch Dermatol 1989;125:1436.

  • Ho VC, Conklin RJ. Effect of topical cyclosporine on oral lichen planus. N Engl J Med 1991;325:435.

  • Harpenau LA, Plemons JM, Rees TD. Effectiveness of a low dose of cyclosporine in the management of patients with oral erosive lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;80:161–167.

  • Levell NJ, MacLeod RI, Marks JM. Lack of effect of cyclosporin mouthwash in oral lichen planus. Lancet 1991;337:796–797.

  • Sieg P, von Domarus H, von Zitzewitz V, Iven H, Färber L. Topical cyclosporin in oral lichen planus: a controlled, randomised, prospective trial. Br J Dermatol 1995;132:790–794.

  • Gombos F, Cappello B, Gaeta GM, La Rotonda MI, Serpico R, Miro A. La ciclosporina in formulazione bioadesiva nella terapia del lichen planus orale erosivo. Minerva Stomatol 1992;41:385–389.

  • Voûte ABE, Schulten EAJM, Langendijk PNJ, Nieboer C, van der Waal I. Cyclosporin A in an adhesive base for treatment of recalcitrant oral lichen planus. Oral Surg Oral Med Oral Pathol 1994;78:437–441.

  • Epstein JB, Truelove EL. Topical cyclosporine in a bioadhesive for treatment of oral lichenoid mucosal reactions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82:532–536.

  • Gunther SW. Vitamin A acid in treatment of oral lichen planus. Arch Dermatol 1973;107:277.

  • Ebner H, Mischer P, Raff M. Lokal behandlung des lichen rubber planus der mundehlermhaut mit vitamin A savre. Z Hautk 1973;48:735–740.

  • Sloberg K, Hersle K, Mobacken H, Thilander H. Topical tretinoin therapy in oral lichen planus. Arch Dermatol 1979;115:716–718.

  • Giustina TA, Stewart JCB, Ellis CN et al. Topical application of isotretinoin gel improves oral lichen planus. Arch Dermatol 1986;122:534–536.

  • Hersle K, Mobacken H, Sloberg K, Thilander H. Severe oral lichen planus: treatment with an aromatic retinoid (etretinate). Br J Dermatol 1982;106:77–80.

  • Ferguson MM, Simpson MB, Hammersley N. The treatment of erosive lichen planus with a retinoidetretinate. Oral Surg Oral Med Oral Pathol 1984;58:283–287.

  • Gorsky M, Raviv M. Efficacy of etretinate (Tigason) in symptomatic oral lichen planus. Oral Surg Oral Med Oral Pathol 1992;73:52–55.

  • Bollag W, Ott F. Treatment of lichen planus with temarotene. Lancet 1989;ii:974.

  • Tradati N, Chiesa F, Rossi N et al. Successful topical treatment of oral lichen planus and leukoplakias with fenretinide (4HPR). Cancer Lett 1994;76:109–111.


Abstract Views: 664

PDF Views: 0




  • A Study of Role of Tacrolimus in the Treatment of Lichen Planus

Abstract Views: 664  |  PDF Views: 0

Authors

Runuk Singhi
Dept of Oral Medicine and Radiology, Dr. D. Y Patil Dental College and Hospital, Navi Mumbai, Maharashtra, India
Sonal Vahanwala
Dept of Oral Medicine and Radiology, Dr. D. Y Patil Dental College and Hospital, Navi Mumbai, Maharashtra, India
Sandeep Pagare
Dept of Oral Medicine and Radiology, Dr. D. Y Patil Dental College and Hospital, Navi Mumbai, Maharashtra, India

Abstract


Oral lichen planus is a chronic inflammatory immunological reaction in which epidermal or epithelial basal cell damage produces mucocutaneous lesions of various types anticipated to occur in 0.5 to 1 % of adult individuals of the middle ages, consequential in mucosal ulceration and scarring. The basis of this study is to explore the usefulness of tacrolimus to treat the oral lesion of lichen planus. Consequently, in the present study we have included a group of patients having oral lichen planus, we intend to uncover a collateral therapy for oral lichen planus other than corticosteroids which has been the mainstay of treatment since their introduction decades ago.

Keywords


Lichen Planus, Tacrolimus, Immunomodulators.

References