International Journal of Contemporary Medicine

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Serum Levels of Renal Parameters in Light, Moderate and Heavy Drinkers: A Relation to Pattern of Alcohol Intake


Affiliations
1 Department of Biochemistry, Karpaga Vinayaga Institute of Medical Sciences, Maduranthagam, Tamilnadu, India
2 Department of Biochemistry, Sri Jayadeva Institute of Cardiology, Bangalore, Karnataka, India
3 Department of Biochemistry, Dr. B.R. Ambedkar Medical College , Bangalore, India
     

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Objective: The purpose of this study was to detect serum levels of renal parameters in light, moderate and heavy drinkers and to evaluate the relation with pattern of alcohol intak.

Methods: 30 males of age 30-50 yrs with regular intake of alcohol for at least 10 yrs were selected and 30 normal male subjects with no history of drinking were selected for controls. The cases were further divided to light, moderate and heavy drinkers depending on pattern of alcohol intake. Renal parameters involve serum urea, creatinine and creatinine clearance.

Results: The study showed increase in serum urea and creatinine levels in heavy drinkers when compared to light and moderate drinkers and decrease in creatinine clearance in heavy drinkers.

Conclusion: The study shows an increase in urea and creatinine levels and decrease in creatinine clearance in heavy drinkers. This shows that pattern of alcohol intake alters the renal function.


Keywords

Urea, Creatinine, Creatinine Clearance, Light Drinkers, Moderate Drinkers, Heavy Drinkers.
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  • Parry. Charles B. H, 2000. Alcohol problems in developing countries: Challenges for the millenium, Suchtmed 2(4) 216-220.

  • Vaswani M, Rao RV. Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis. Indian J Med Sci, 2005; Vol 59: 423-430.

  • Sheila Sherlock and James Dooley. Alcohol and the Liver, Diseases of Liver and Biliary system, 11th edition, Blackwell publications, London: 384-385.

  • M. N. Chatterjea, Rana Shinde. Diet and Nutrition, Textbook of Medical Biochemistry, 7th edition: 721-722.

  • Alan H. Gowenlock. Varley’s Practical Clinical Biochemistry. Creatinine, Urate and Urea, 6th edition: 350-367.

  • Tietz Nw, ed. Clinical guide to laboratory tests. 3 rd edition. 1995, Philadelphia, Saunders

  • Lawrence A. Kaplan. Textbook of Clinical Chemistry Theory, Analysis, Correlation, 4th edition. Renal function: 477-492.

  • Bernard Rosner (2000), Fundamentals of Biostatistics, 5th Edition, Duxbury, page 80-240

  • Sunder Rao P S S, Richard J: An Introduction to Biostatistics, A manual for students in health sciences, New Delhi: Prentice hall of India. 86-160

  • DM Vasudevan, Sreekumari. Textbook of Biochemistry. Minor metabolic pathways of carbohydrates, 4th edition: 115 – 126.

  • DM Vasudevan, Sreekumari. Textbook of Biochemistry. Minor metabolic pathways of carbohydrates, 4th edition: 115 – 126.

  • Eric L. Knight, Meir J. Stampfer et al. Moderate alcohol intake and renal function in women: a prospective study.2005.

  • Elke S. Schaffner, Tobias Kurth et al. Alcohol consumption and the risk of renal dysfunction in apparently healthy men. Arch Intern Med; 165: 1048-1053.

  • Majumdar SK, Shaw GK, O’ Gorman P et al. Plasma urea and creatinine status in chronic alcoholics. Drug Alcohol Dependence, 1982; 9(2): 97-100.

  • Fu- Mei Chung, Yi Hsin Tien et al. Effect of alcohol consumption on estimated glomerular filtration rate and creatinine clearance rate. Nephrology Dialysis Transplant. 2005:1610-1616.


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  • Serum Levels of Renal Parameters in Light, Moderate and Heavy Drinkers: A Relation to Pattern of Alcohol Intake

Abstract Views: 481  |  PDF Views: 0

Authors

Singaravelu Swetha
Department of Biochemistry, Karpaga Vinayaga Institute of Medical Sciences, Maduranthagam, Tamilnadu, India
K C Sheethal
Department of Biochemistry, Sri Jayadeva Institute of Cardiology, Bangalore, Karnataka, India
Shanthakumari
Department of Biochemistry, Dr. B.R. Ambedkar Medical College , Bangalore, India

Abstract


Objective: The purpose of this study was to detect serum levels of renal parameters in light, moderate and heavy drinkers and to evaluate the relation with pattern of alcohol intak.

Methods: 30 males of age 30-50 yrs with regular intake of alcohol for at least 10 yrs were selected and 30 normal male subjects with no history of drinking were selected for controls. The cases were further divided to light, moderate and heavy drinkers depending on pattern of alcohol intake. Renal parameters involve serum urea, creatinine and creatinine clearance.

Results: The study showed increase in serum urea and creatinine levels in heavy drinkers when compared to light and moderate drinkers and decrease in creatinine clearance in heavy drinkers.

Conclusion: The study shows an increase in urea and creatinine levels and decrease in creatinine clearance in heavy drinkers. This shows that pattern of alcohol intake alters the renal function.


Keywords


Urea, Creatinine, Creatinine Clearance, Light Drinkers, Moderate Drinkers, Heavy Drinkers.

References