Indian Journal of Drugs and Diseases

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Immunomodulatory Effect of Withania Somnifera in Broilers Treated with High Doses of Enrofloxacin


Affiliations
1 Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal -637 002, Tamil Nadu, India
 

The effect of supplementation of Withania somnifera extract on immunomodulatory response in broilers treated with high doses of enrofloxacin in poultry was investigated. Ninety day old broiler chicks of either sex were randomly divided into nine groups of 10 each. Enrofloxacin was administered at 30 and 40 mg/kg orally for seven days during the third week and W. somnifera crude extract was added in the feed at 1 and 2 % from second week onwards and the effect of their combinations was evaluated. The results of the study revealed that enrofloxacin treatment produced highly significant reduction in serum total protein, albumin and globulin and numerical decrease in HI titre against Newcastle vaccine. The groups treated with W. somnifera alone did not differ significantly from the control in all above parameters. Dose dependent increase in all the parameters were noticed in the combination groups which clearly supports the immunoprotective effect of W. somnifera.

Keywords

Broilers, Immunomodulatory, Withania Somnifera, Enrofloxacin, HI Titre
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  • Immunomodulatory Effect of Withania Somnifera in Broilers Treated with High Doses of Enrofloxacin

Abstract Views: 377  |  PDF Views: 394

Authors

A. Arivuchelvan
Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal -637 002, Tamil Nadu, India
S. Murugesan
Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal -637 002, Tamil Nadu, India
P. Mekala
Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal -637 002, Tamil Nadu, India

Abstract


The effect of supplementation of Withania somnifera extract on immunomodulatory response in broilers treated with high doses of enrofloxacin in poultry was investigated. Ninety day old broiler chicks of either sex were randomly divided into nine groups of 10 each. Enrofloxacin was administered at 30 and 40 mg/kg orally for seven days during the third week and W. somnifera crude extract was added in the feed at 1 and 2 % from second week onwards and the effect of their combinations was evaluated. The results of the study revealed that enrofloxacin treatment produced highly significant reduction in serum total protein, albumin and globulin and numerical decrease in HI titre against Newcastle vaccine. The groups treated with W. somnifera alone did not differ significantly from the control in all above parameters. Dose dependent increase in all the parameters were noticed in the combination groups which clearly supports the immunoprotective effect of W. somnifera.

Keywords


Broilers, Immunomodulatory, Withania Somnifera, Enrofloxacin, HI Titre

References