Indian Journal of Drugs and Diseases

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Farnesol Wins the Wrestle against 'Biofilm Associated Protein (BAP)' of Staphlyococcus epidermidis


Affiliations
1 Dept. of Bioinformatics, Sri Ramachandra University, Chennai – 116, India
2 Dept. of Biomedical Sciences, Sri Ramachandra University, Chennai – 116, India
3 Dept. of Microbiology, Sri Ramachandra University, Chennai – 116, India
4 Animal Research, PRIST University, Chennai - 603002, India
5 Dept. of Microbiology, Kilpauk Medical College, Chennai - 10, India
 

Background/Objectives: Using simple in silico genomic and proteomic techniques, this study is an approach to identify some molecules against the biofilm associated protein (bap) protein of Staphylococcus epidermidis. 'bap' is a gene that is associated with biofilm formation in many Staphylococcus species, which cause biofilms in venous catheters of indwelling medical devices.

Methods/Statistical analysis: Various genomic and proteomic analyses revealed that 'bap' has a good scope as a target to combat biofilms on indwelling medical devices.

Results: Farnesol, a terpenoid by nature exhibited very good binding with the 'bap' protein compared to other molecules of similar structures, when docked with Hex 4.2.

Conclusion/Application: Further analyses on other associated natural compounds on other genes which promote adherence of biofilms, may reveal their capacity to inhibit the biofilm formation on medical devices, which will be a boon to both doctors and patients alike.


Keywords

Biofilm, Bap, Farnesol, Staphylococcus epidermidis, Venous Catheters, Indwelling Medical Devices.
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  • Farnesol Wins the Wrestle against 'Biofilm Associated Protein (BAP)' of Staphlyococcus epidermidis

Abstract Views: 295  |  PDF Views: 158

Authors

C. R. Hemalatha
Dept. of Bioinformatics, Sri Ramachandra University, Chennai – 116, India
S. Archana
Dept. of Biomedical Sciences, Sri Ramachandra University, Chennai – 116, India
Anupma Jyoti Kindo
Dept. of Microbiology, Sri Ramachandra University, Chennai – 116, India
P. Dhanapalan
Animal Research, PRIST University, Chennai - 603002, India
Thyagarajan Ravinder
Dept. of Microbiology, Kilpauk Medical College, Chennai - 10, India

Abstract


Background/Objectives: Using simple in silico genomic and proteomic techniques, this study is an approach to identify some molecules against the biofilm associated protein (bap) protein of Staphylococcus epidermidis. 'bap' is a gene that is associated with biofilm formation in many Staphylococcus species, which cause biofilms in venous catheters of indwelling medical devices.

Methods/Statistical analysis: Various genomic and proteomic analyses revealed that 'bap' has a good scope as a target to combat biofilms on indwelling medical devices.

Results: Farnesol, a terpenoid by nature exhibited very good binding with the 'bap' protein compared to other molecules of similar structures, when docked with Hex 4.2.

Conclusion/Application: Further analyses on other associated natural compounds on other genes which promote adherence of biofilms, may reveal their capacity to inhibit the biofilm formation on medical devices, which will be a boon to both doctors and patients alike.


Keywords


Biofilm, Bap, Farnesol, Staphylococcus epidermidis, Venous Catheters, Indwelling Medical Devices.