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Authors
Affiliations
1 Dept. of Bioinformatics, Sri Ramachandra University, Chennai – 116, IN
2 Dept. of Biomedical Sciences, Sri Ramachandra University, Chennai – 116, IN
3 Dept. of Microbiology, Sri Ramachandra University, Chennai – 116, IN
4 Animal Research, PRIST University, Chennai - 603002, IN
5 Dept. of Microbiology, Kilpauk Medical College, Chennai - 10, IN
Source
Indian Journal of Drugs and Diseases, Vol 3, No 2 (2014), Pagination: 311-316
Abstract
Background/Objectives: Using simple in silico genomic and proteomic techniques, this study is an approach to identify some molecules against the biofilm associated protein (bap) protein of Staphylococcus epidermidis. 'bap' is a gene that is associated with biofilm formation in many Staphylococcus species, which cause biofilms in venous catheters of indwelling medical devices.
Methods/Statistical analysis: Various genomic and proteomic analyses revealed that 'bap' has a good scope as a target to combat biofilms on indwelling medical devices.
Results: Farnesol, a terpenoid by nature exhibited very good binding with the 'bap' protein compared to other molecules of similar structures, when docked with Hex 4.2.
Conclusion/Application: Further analyses on other associated natural compounds on other genes which promote adherence of biofilms, may reveal their capacity to inhibit the biofilm formation on medical devices, which will be a boon to both doctors and patients alike.
Keywords
Biofilm, Bap, Farnesol, Staphylococcus epidermidis, Venous Catheters, Indwelling Medical Devices.
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