Indian Journal of Forensic Medicine & Toxicology

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Pulmonary Responses of Manufactured Ultrafine Aluminum Oxide Particles Upon Repeated Exposure by Inhalation in Rats


Affiliations
1 IIBAT, Padappai, Tamil Nadu, India
2 Pathologist, IIBAT, Padappai, Tamil Nadu, India
3 CLRI, Chennai, India
     

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The aim of this study is to evaluate the pulmonary effects of manufactured ultra fine (10 nm) aluminum oxide particles (UFAOP) upon repeated exposure by inhalation. Rats were exposed with UFAOP in nose-only inhalation chambers at concentrations of 0, 50, 100, and 160 mg/m3 for 6h per day on 5 days. Bronchoalveolar lavage analysis showed pulmonary inflammation and cytotoxicity. Histopathology of lungs showed particle induced cytotoxicity and inflammation characterized by mononuclear inflammatory cell infiltration. Lung burden data showed less percentage of clearance and higher biological half time for UFAOP. Based on our results we conclude that repeated inhalation exposure of UFAOP induced concentration dependant toxicity to lungs of rats at different time points of post exposure.

Keywords

UFAOP Inhalation Inflammation Nanoparticles
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  • Pulmonary Responses of Manufactured Ultrafine Aluminum Oxide Particles Upon Repeated Exposure by Inhalation in Rats

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Authors

P. V. Rajsekhar
IIBAT, Padappai, Tamil Nadu, India
G. Selvam
Pathologist, IIBAT, Padappai, Tamil Nadu, India
A. Goparaju
IIBAT, Padappai, Tamil Nadu, India
P. Balakrishna Murthy
IIBAT, Padappai, Tamil Nadu, India
P. Neelakanta Reddy
CLRI, Chennai, India

Abstract


The aim of this study is to evaluate the pulmonary effects of manufactured ultra fine (10 nm) aluminum oxide particles (UFAOP) upon repeated exposure by inhalation. Rats were exposed with UFAOP in nose-only inhalation chambers at concentrations of 0, 50, 100, and 160 mg/m3 for 6h per day on 5 days. Bronchoalveolar lavage analysis showed pulmonary inflammation and cytotoxicity. Histopathology of lungs showed particle induced cytotoxicity and inflammation characterized by mononuclear inflammatory cell infiltration. Lung burden data showed less percentage of clearance and higher biological half time for UFAOP. Based on our results we conclude that repeated inhalation exposure of UFAOP induced concentration dependant toxicity to lungs of rats at different time points of post exposure.

Keywords


UFAOP Inhalation Inflammation Nanoparticles

References