Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Hypotonia - A Rare Complication of 2, 4-D Amine Poisoning


Affiliations
1 Department of Medicine, Krishna Institute of Medical Sciences University, Dhebewadi Road, Karad, Dist. Satara, Maharashtra State, India
     

   Subscribe/Renew Journal


2,4-D amine is the commonly used herbicide along with the most poorly, understudied compound in the form of its toxic effects in humans. We hereby present a case of suicidal attempt by a male patient involving the ingestion of 2,4-D who presented with generalized hypotonia 1 hr after the ingestion of the compound. The patient was brought in a semiconscious, hyporeflexic state with signs of raised intracranial pressure. After proper treatment in the form of diuresis and other symptomatic care, he recovered fully with no residual neurodeficit.

Keywords

2,4-D amine, Hypotonia
Subscription Login to verify subscription
User
Notifications
Font Size


  • 24d.org Industry Task Force II on 2,4-D Research Data
  • See the review article: J. H. Quastel, “2,4- dichlorophenoxyacetic acid (2,4-D) as a selective herbicide,” Agricultural Control Chemicals (Washington, D.C.: American Chemical Society, 1950), Chapter 45, pages 244-249.
  • Extension Toxicology Network (1996) Extoxnet pesticide information profile: 2,4-D. Oregon State University and U.S. EPA. Available at http:// ace.orst.edu/info/extoxnet/pips/24-D.htm. (Accessed August 5, 2005)
  • Wilson BW (2001) Cholinesterases. In Krieger RI, ed., Handbook of Pesticide Toxicology (2 Vols.). Academic Press, San Diego, pp. 967-985.
  • Hantson P, Wallemacq P, Mahieu P (2000) A case of fatal diquat poisoning: toxicokinetic data and autopsy findings. J Toxicol Clin Toxicol 38, 149-152.
  • Klein-Schwartz W, Smith GS (1997) Agricultural and horticultural chemical poisonings: mortality and morbidity in United States. Ann Emerg Med 29, 232-238.
  • Rivers JB, Yauger WL, Klemmer HW (1970) Simultaneous gas chromatographic determination of 2,4-D and dicamba in human blood and urine. J Chromatogr 50, 334-337.
  • DeLarrard J, Barbaste M (1969) Fatal suicidal poisoning due to 2,4-D. Arch Mal Prof Med Trav Secur Soc 30, 434.
  • Dudley AW Jr, Thapar NT (1972) Fatal human ingestion of 2,4-D, a common herbicide. Arch Pathol 94, 270-275.
  • Pillay VV (2003) Comprehensive Medical Toxicology. Paras Publishing, Hyderabad, India.
  • Jeyaratnam J (1990) Acute pesticide poisoning: a major global health problem. World Health Stat Q 43, 139-144.
  • De Alwis LB, Salgado MS (1988) Agrochemical poisoning in Sri Lanka. Forensic Sci Int 36, 81-89.
  • Zahm, Shelia Hoar; Weisenburger, Dennis D.; Babbitt, Paula A.; Saal, Robert C.; Vaught, Jimmie B.; Cantor, Kenneth P.; Blair, Aaron, “A Case- Control Study of Non-Hodgkin’s Lymphoma and the Herbicide 2,4-Dichlorophenoxyacetic Acid (2, 4-D) in Eastern Nebraska”, Epidemiology, Vol. 1, No. 5., Sep. 1990.
  • “C J Burnsa, K K Beardb, J B Cartmill, “Mortality in chemical workers potentially exposed to 2,4- dichlorophenoxyacetic acid (2,4-D) 1945-94: an update”, Occupational and Environmental Medicine, Vol. 58, pp. 24-30, 2001.”. Archived from the original on 2009-05-14. http://oem.bmj.com/ cgi/content/abstract/58/1/24. Retrieved 2009- 05-08.
  • Lerda, D; Rizzi, R (1991). “Study of reproductive function in persons occupationally exposed to 2,4- dichlorophenoxyacetic acid (2,4-D)”. Mutation research 262 (1): 47–50. PMID 1986284.
  • Roberts DM, Buckley NA (2007). Roberts, Darren M. ed. “Urinary alkalinisation for acute chlorophenoxy herbicide poisoning”. Cochrane Database Syst Rev (1): CD005488. doi:10.1002/ 14651858.CD005488.pub2. PMID 17253558.

Abstract Views: 286

PDF Views: 0




  • Hypotonia - A Rare Complication of 2, 4-D Amine Poisoning

Abstract Views: 286  |  PDF Views: 0

Authors

S. C. Aundhakar
Department of Medicine, Krishna Institute of Medical Sciences University, Dhebewadi Road, Karad, Dist. Satara, Maharashtra State, India
Sanket K. Mahajan
Department of Medicine, Krishna Institute of Medical Sciences University, Dhebewadi Road, Karad, Dist. Satara, Maharashtra State, India
Dhanesh M. Mhaskar
Department of Medicine, Krishna Institute of Medical Sciences University, Dhebewadi Road, Karad, Dist. Satara, Maharashtra State, India
Shirish M. Agrawal
Department of Medicine, Krishna Institute of Medical Sciences University, Dhebewadi Road, Karad, Dist. Satara, Maharashtra State, India

Abstract


2,4-D amine is the commonly used herbicide along with the most poorly, understudied compound in the form of its toxic effects in humans. We hereby present a case of suicidal attempt by a male patient involving the ingestion of 2,4-D who presented with generalized hypotonia 1 hr after the ingestion of the compound. The patient was brought in a semiconscious, hyporeflexic state with signs of raised intracranial pressure. After proper treatment in the form of diuresis and other symptomatic care, he recovered fully with no residual neurodeficit.

Keywords


2,4-D amine, Hypotonia

References