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Synthesis, Characterization, Biological and Catalytic Activity of Carboxymethyl Chitosan Schiff Base Metal Complexes


Affiliations
1 Government, Polytechnic College, Nagapadi, Tiruvannamalai, Tamil Nadu – 606 705, India
2 Department of Chemistry, Muthurangam Govt. Arts College, Vellore, Tamil Nadu – 632 002, India
3 PG & Research Department of Chemistry, D.K.M College for Women, Vellore, Tamil Nadu – 632 001, India
4 Government Girls Higher Secondary School, Kanji, Tiruvannamalai, Tamil Nadu – 606 702, India
 

The Schiff base of carboxymethyl chitosan/p-dimethylaminobenzaldehyde (CMC-SB), as well as its complexes with cobalt (CMC-SB-Co), nickel (CMC-SB-Ni), and zinc (CMC-SB-Zn), were synthesised and studied using FTIR, XRD, TGA, DSC, and SEM. Schiff base metal complex production has been verified by the FTIR and XRD data. According to the thermal studies, the CMC-SB Zinc combination has better thermal stability than other complexes. The material is porous and rough, and the SEM results show that it has several potential uses in the biological field. The zinc complexes have increased activity when it comes to catalysis. It has been determined by the MTT test and ALP activity that the synthesised sample is non-toxic, compatible, and has good antioxidant activity.

Keywords

Carboxymethyl Chitosan, Schiff Base, Catalytic Activity.
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  • Shahidi F, Arachchi J K V & Jeon Y J, Food applications of chitin and chitosan, Trends Food Sci Technol, 10 (1999)

  • 37–51.

  • Daniel E-A-K & Hamblin M R, Chitin and Chitosan: Production and Application of Versatile Biomedical Nanomaterials, Intnl J Adv Res, 4 (2016) 411-427.

  • Muzzarelli R A A, Carboxymethylated chitins and chitosans, Carbohyd Polymers, 8 (1988) 1–21.

  • Swain P K, Das M & Nayak P L, Comparative study of controlled release mechanism of curcumin from different polymer matrices, Intnl J Plant, Animal Environ Sci, 6 (2016) 245-254.

  • Montaser A S, Physical, Mechanical and Antimicrobial Evaluations of Physically Crosslinked PVA/Chitosan Hydrogels Containing Nanoparticles, J Appl Pharm Sci, 6 (2016) 001-006.

  • Chen L, Du Y, Tian Z & Sun L, Effect of the degree of deacetylation and the substitution of carboxymethyl chitosan on its aggregation behavior, J Polym Sci Polym Phys, 43 (2005) 296–305.

  • Liu Z, Jiao Y & Zhang Z, Calcium-carboxymethyl chitosan hydrogel beads for protein drug delivery system, J Appl Polym Sci, 103 (2007) 3164–3168.

  • Janvikul W & Thavornyutikarn B, New route to the preparation of Carboxymethyl chitosan hydrogels, J Appl Polym Sci, 90 (2003) 4016–4020.

  • Muzzarelli R A A, Ramos V, Stanic V & Dubini B, Osteogenesis promoted by calcium phosphate N,N-dicarboxymethyl chitosan, Carbohyd Polym, 36 (1998) 267–276.

  • Kurita K, Mori S, Nishiyama Y & Harata M, N-Alkylation of chitin and some characteristics of the novel derivatives, Polym Bull, 48 (2002) 159-166.

  • Moore G K & Roberts G A F, A Compound Hydrodynamic Shape Function Derived from Viscosity and Molecular Covolume Measurements, Int J Biol Macro, 3 (1981) 337-341.

  • Vasak B, Gavalyan, Synthesis and characterization of new chitosan-based Schiff base compounds, Carbohyd Poly, 145 (2016) 37-47.

  • Rani J & Bheeter, Synthesis and characterization of Schiff base metal complexes derived from 3-ethoxysalicylaldehyde and 2-amino-4-methyl phenol, World J Pharm Pharmactl Sci, 5 (2016) 895-904.

  • Suresh R, Moganavally P, Deepa M & Sudha P N, Synthesis, Characterization and biological activity of Carboxymethyl chitosan/p-dimethylamino Benzaldehyde metal complexes, J Chem Pharm Res, 7 (2015) 1044-1049.

  • Pradhan S, Ward W, Hacioglu K, Martin J & Jurafsky D, Semantic role labeling using different syntactic views, In: Proceedings of the Association for Computational Linguistics 43rd annual meeting (ACL- 2005), University of Michigan, USA.

  • Kumar S & Joonseok K, Physiochemical, optical and biological activity of chitosan-chromone derivative for biomedical applications, Int J Mol Sci, 13 (5) (2012) 6102-6116.

  • Li Xuebo, Jiang F, Liu M, Qu Y, Lan Z, et al., Synthesis, Characterization, and Bioactivities of Polysaccharide Metal Complexes: A Review, J Agril Food Chem, 70 (23) (2022) 6922–6942.

  • Khalil A M, Reham A A-M, Osama M D, Ahmed I H, Afaf A N, et al., Synthesis, characterization, and evaluation of antimicrobial activities of chitosan and carboxymethyl chitosan schiff-base/silver nanoparticles, J Chem, 2017 (2017) pp. 11.

  • Ma Z-Y, Xin Q, Xie C-Z, Shao J, Xu J-Y, et al., Activities of a novel Schiff Base copper (II) complex on growth inhibition and apoptosis induction toward MCF-7 human breast cancer cells via mitochondrial pathway, J Inorg Biochem, 117 (2012) 1-9.

  • Abeyrathne E D N S, Nam K & Ahn D U, Analytical methods for lipid oxidation and antioxidant capacity in food systems, Antioxidants, 10 (10) (2021) p. 1587.

  • Yuan H-X, Xia Q-H, Zhan H-J, Lu X-H & Su K-X, Catalytic oxidation of cyclohexane to cyclohexanone and cyclohexanol by oxygen in a solvent-free system over metal-containing ZSM-5 catalysts, Appl Catal A: Gen, 304 (2006) 178-184.

  • Schuchardt U, Carvalho W A & Spinace E V, Why is it Interesting to Study Cyclohexane Oxidation? Synlett, 10 (1993) 713-718.

  • Feng Z-Q, Yang X-L & Ye Y-F, Pd (II) and Zn (II) based complexes with Schiff base ligands: Synthesis, characterization, luminescence, and antibacterial and catalytic activities, The Scific World J, (2013) pp. 9. https://doi.org/10.1155/2013/956840


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  • Synthesis, Characterization, Biological and Catalytic Activity of Carboxymethyl Chitosan Schiff Base Metal Complexes

Abstract Views: 123  |  PDF Views: 87

Authors

R. Suresh
Government, Polytechnic College, Nagapadi, Tiruvannamalai, Tamil Nadu – 606 705, India
M. Deepa
Department of Chemistry, Muthurangam Govt. Arts College, Vellore, Tamil Nadu – 632 002, India
P. N. Sudha
PG & Research Department of Chemistry, D.K.M College for Women, Vellore, Tamil Nadu – 632 001, India
T. Gomathi
PG & Research Department of Chemistry, D.K.M College for Women, Vellore, Tamil Nadu – 632 001, India
S. Pavithra
PG & Research Department of Chemistry, D.K.M College for Women, Vellore, Tamil Nadu – 632 001, India
P. Moganavally
Government Girls Higher Secondary School, Kanji, Tiruvannamalai, Tamil Nadu – 606 702, India

Abstract


The Schiff base of carboxymethyl chitosan/p-dimethylaminobenzaldehyde (CMC-SB), as well as its complexes with cobalt (CMC-SB-Co), nickel (CMC-SB-Ni), and zinc (CMC-SB-Zn), were synthesised and studied using FTIR, XRD, TGA, DSC, and SEM. Schiff base metal complex production has been verified by the FTIR and XRD data. According to the thermal studies, the CMC-SB Zinc combination has better thermal stability than other complexes. The material is porous and rough, and the SEM results show that it has several potential uses in the biological field. The zinc complexes have increased activity when it comes to catalysis. It has been determined by the MTT test and ALP activity that the synthesised sample is non-toxic, compatible, and has good antioxidant activity.

Keywords


Carboxymethyl Chitosan, Schiff Base, Catalytic Activity.

References