Indian Journal of Health and Wellbeing

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Antiglycation and Antioxidative Properties of Fumaria Indica Various Fractions: Role in Reducing Diabetic Complications and Ageing


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1 Centre of Biotechnology and Microbiology, University of Peshawar, Khyber Pukhtoon Khwa, Pakistan, India
 

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Over the centuries medicinal plants have benefited mankind against different diseases. Advanced glycation end-products (AGE's) formation due to non-enzymatic glycation and oxidative stress has been demonstrated in the pathogenesis of diabetic complications and aging processes. In this study we investigated the antiglycation and antioxidation potential of different fraction F. indica whole plant. Our results indicated that the chloroform fraction of B. bulbocastanumfruitshad more antiglycation ability with a Minimum inhibitory concentration (MIC50) of 148.96 µg/mL as compared to the MIC50 of 221.96, 270.00, 294.01 and 322.49µg/ml of aqueous, ethyl acetate, n-hexane and crude methanolic fractions, respectively. While the results of antioxidation assay showed that chloroform fraction has more antioxidation potential than the standard (ascorbic acid) at 0.5 mg/ml concentration. Chloroform, ethyl acetate, aqueous, n-hexane and crude methanolic fractions had 29.39, 21.41, 15.25, 13.01and 11.33 % antioxidation potential at 0.5 mg / ml respectively.
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  • Antiglycation and Antioxidative Properties of Fumaria Indica Various Fractions: Role in Reducing Diabetic Complications and Ageing

Abstract Views: 456  |  PDF Views: 333

Authors

Haroon Ahmad
Centre of Biotechnology and Microbiology, University of Peshawar, Khyber Pukhtoon Khwa, Pakistan, India
Ibrar Khan
Centre of Biotechnology and Microbiology, University of Peshawar, Khyber Pukhtoon Khwa, Pakistan, India

Abstract


Over the centuries medicinal plants have benefited mankind against different diseases. Advanced glycation end-products (AGE's) formation due to non-enzymatic glycation and oxidative stress has been demonstrated in the pathogenesis of diabetic complications and aging processes. In this study we investigated the antiglycation and antioxidation potential of different fraction F. indica whole plant. Our results indicated that the chloroform fraction of B. bulbocastanumfruitshad more antiglycation ability with a Minimum inhibitory concentration (MIC50) of 148.96 µg/mL as compared to the MIC50 of 221.96, 270.00, 294.01 and 322.49µg/ml of aqueous, ethyl acetate, n-hexane and crude methanolic fractions, respectively. While the results of antioxidation assay showed that chloroform fraction has more antioxidation potential than the standard (ascorbic acid) at 0.5 mg/ml concentration. Chloroform, ethyl acetate, aqueous, n-hexane and crude methanolic fractions had 29.39, 21.41, 15.25, 13.01and 11.33 % antioxidation potential at 0.5 mg / ml respectively.