Indian Journal of Medicine and Healthcare

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Drug likeliness of 3,6-diisopropyl-2,5-piperazinedione - produced by Marine Sponge Associated Bacteria Rhodopseudomonas palustris MSB 55


Affiliations
1 Department of Biotechnology, Hindustan College of Arts and Science, Padur,Chennai - 603103, India
2 Department of Bioinformatics, Bharathidasan University, Trichi, India
 

Drug discovery and development is an intense, lengthy and an interdisciplinary endeavour. Drug discovery is mostly portrayed as a linear, consecutive process that starts with target and lead discovery, followed by lead optimization and pre-clinical in vitro and in vivo studies to determine if such compounds satisfy a number of pre-set criteria for initiating clinical development. In this present study a sponge Axinella donani was collected from Kanyakumari coast line and their associated bacteria were isolated and identified. Various therapeutic compounds were identified by the techniques such as spectroscopic and chromatographic methods. Drug likeliness of 3,6-diisopropyl-2,5-piperazinedione - produced by Rhodopseudomonas palustris MSB 55 was studied by Autodock from this study, it was found to be a Neuronal Nicotinic receptor served as target for 3,6-diisopropyl-2,5-piperazinedione. ADME/TOX tool helped to find out whether the molecule is obeying Lipinski's Rule of Five to evaluate drug likeness. From the present study it could be concluded that the sponge associated bacteria can serve as a source for therapeutic compounds.

Keywords

Axinella donani, Rhodopseudomonas palustris, MSB 55, 3,6-diisopropyl-2,5-piperazinedione, Neuronal Nicotinic Receptor, Autodock, ADME/TOX
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  • Drug likeliness of 3,6-diisopropyl-2,5-piperazinedione - produced by Marine Sponge Associated Bacteria Rhodopseudomonas palustris MSB 55

Abstract Views: 522  |  PDF Views: 377

Authors

C. E. Rani Juneius
Department of Biotechnology, Hindustan College of Arts and Science, Padur,Chennai - 603103, India
J. Selvin
Department of Bioinformatics, Bharathidasan University, Trichi, India

Abstract


Drug discovery and development is an intense, lengthy and an interdisciplinary endeavour. Drug discovery is mostly portrayed as a linear, consecutive process that starts with target and lead discovery, followed by lead optimization and pre-clinical in vitro and in vivo studies to determine if such compounds satisfy a number of pre-set criteria for initiating clinical development. In this present study a sponge Axinella donani was collected from Kanyakumari coast line and their associated bacteria were isolated and identified. Various therapeutic compounds were identified by the techniques such as spectroscopic and chromatographic methods. Drug likeliness of 3,6-diisopropyl-2,5-piperazinedione - produced by Rhodopseudomonas palustris MSB 55 was studied by Autodock from this study, it was found to be a Neuronal Nicotinic receptor served as target for 3,6-diisopropyl-2,5-piperazinedione. ADME/TOX tool helped to find out whether the molecule is obeying Lipinski's Rule of Five to evaluate drug likeness. From the present study it could be concluded that the sponge associated bacteria can serve as a source for therapeutic compounds.

Keywords


Axinella donani, Rhodopseudomonas palustris, MSB 55, 3,6-diisopropyl-2,5-piperazinedione, Neuronal Nicotinic Receptor, Autodock, ADME/TOX

References