Indian Journal of Medicine and Healthcare

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Ameliorative Potential of Aqueous Extract of Talinum triangulare on Diabetes Associated Metabolic Alterations.


Affiliations
1 Department of Medical Biochemistry, Gayatri Vidya Parishad Health Care and Medical Technology , Marikavalasa, Maridivaly , Visakhapatnam , Pincode-48,Andhra Pradesh, India
 

Oral administration of aqueous extract of Talinum triangulare to diabetic rats secluded the rats from the alterations induced in carbohydrate and lipid metabolism. The raise in the glycosylated hemoglobin is a sign of succession in diabetes. In addition, during diabetes there is an increase in the cholesterol and triglyceride contents. The Supplementation of Talinum triangulare leaf aqueous extract (80mg/kg b.wt) brought the levels of lipids to almost normal by exhibiting antihypoglycemic and antilipidemic properties. The decrease in HDL cholesterol in diabetic rats can be used as a marker in the assessing the severity of diabetes.

Keywords

Talinum triangulare, Hemoglobin, Glucoselevels, Sugar, Lipid profile
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  • Bannon P (1982) Effect of pH on the elimination of the labile fraction of glycosylated hemoglobin. Clin. Chem. 28, 2183. Chandalia HB and Lamda PS ( 2002) Management of diabetes mellitus during Non-Metabolic eme r g i n g situations. Int. J. Diabetes in Developing Countries. 22, 1-11.

  • Chandalia HB and Krishnaswamy PR (2002) Glycated hemoglobin. Curr. Sci. 83,1522-1615.

  • Drabkin DL and Austin JM ( 1932) Spectrophotometric studies, Spectrophotometric constants for common haemoglobin derivatives in human, dog and rabbit blood. J. Biol. Chem. 98,719-733.

  • Gabbay KH (1976) Glycosylated haemoglobin and diabetic control. New England J. Med. 95, 443-454.

  • Jung M, Park M, Lee HC, Kang YH, Kang, E. S. and Kim S. K. (2006). Antidiabetic agents from medicinal plants. Curr. Medicinal Chem. 13, 1203-1218

  • Koening RJ, Peterson CM, Jones RL, Saudek C, Lehrman M and Cerami A ( 1976) Correlation o f glucose re gul a - t i o n a n d hemoglogbin A1C in diabetes mellitus. New Eng. J. Med. 295, 417- 420

  • Kostner GM and Karadi I (1998) Lipoprotein alterations in diabetes mellitus. Diabetologia. 31, 717-722

  • Nayak SS and Pattabiraman TN (1981) A new colorimetric method for common haemoglobin. Clinica Chemica Acta. 109, 267-274.

  • Paulsen EP ( 1973) Heamoglobin A1c in childhood of diabetes. Metabolism. Vo l . 22, pp: 269-271.

  • Saxena A and Kishore VN (2004) Role of selected medicinal Indian plants in management of type 2 Diabetes: A review. J. Alternative & Comlementary Med. 10, 369-378.

  • Szaleczky E, Prechl J, Feher J and Somogyi A (1999) Alteration in enzymatic antioxidant defense in diabetes mellitus- a rational approach. Post Graduate Med. J. 75, 13-17.

  • Sarkar S, Pranava M and Marita RA (1996) Demonstration of the hypoglycemic a c t i on of Momordica charantia in a validated animal model of diabetes. Pharmacol. Res. 33, 1-4.

  • Shirwaikar A, Rajendra K, Kumar CD and Bodla R ( 2004) Antidiabetic activity of aqueous leaf extracts of Annona Squamosa in streptozotocin-nicotinamide type 2 diabetic rats. J. Ethnopharmacol. 91, 171-175.

  • Vats V, Yadav SP and Gover JK (2004) Ethanolic extract of Ocimum Sanctum leaves partially attenuates streptozotocin induced alterations in glycogen content and carbohydrate metabolism in rats. J. Ethnopharmacology. 90,155-160.

  • Ravindra Babu P, Rama Rao D, Prasad Rao M, Krishna Kanth JV, Srinivasulu M and Hareesh V (2012). Hypoglycemic activity of methanolic extract of Talinum triangulare in normal and streptozocin induced diabetic rats. J. Appli.Pharmaceut. Sci. 2(5), 197-201.


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  • Ameliorative Potential of Aqueous Extract of Talinum triangulare on Diabetes Associated Metabolic Alterations.

Abstract Views: 545  |  PDF Views: 361

Authors

J. Sudha Rani
Department of Medical Biochemistry, Gayatri Vidya Parishad Health Care and Medical Technology , Marikavalasa, Maridivaly , Visakhapatnam , Pincode-48,Andhra Pradesh, India

Abstract


Oral administration of aqueous extract of Talinum triangulare to diabetic rats secluded the rats from the alterations induced in carbohydrate and lipid metabolism. The raise in the glycosylated hemoglobin is a sign of succession in diabetes. In addition, during diabetes there is an increase in the cholesterol and triglyceride contents. The Supplementation of Talinum triangulare leaf aqueous extract (80mg/kg b.wt) brought the levels of lipids to almost normal by exhibiting antihypoglycemic and antilipidemic properties. The decrease in HDL cholesterol in diabetic rats can be used as a marker in the assessing the severity of diabetes.

Keywords


Talinum triangulare, Hemoglobin, Glucoselevels, Sugar, Lipid profile

References