Indian Journal of Medicine and Healthcare

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Incidence of Hepatitis G Virus in Patients with Hematological Malignancies with Repeated Blood Transfusion


Affiliations
1 Department of Clinical Hematology, The national center of Hematology, Almustansiriya University
2 Department of Microbiology, University of Baghdad College of Medicine
3 Department of Pathology, University of Baghdad College of Medicine
 

Background: Hepatitis G virus and GB virus C (GBV-C) are RNA viruses that were independently identified in 1995, and were subsequently found to be two isolates of the same virus. Blood transfusion is the main risk factor for HGV transmission. Patients with hematological malignancies usually require frequent blood transfusions which make them more vulnerable to HGV infection. The aims of this study was to estimate the transmission rate of HGV in patients with hematological malignancies having multiple blood transfusion. Methods: This cross sectional study was carried out at the national center of hematology,Almustansiriya University and department of microbiology in Baghdad university college of medicine in Baghdad / Iraq from January till June 2012. The study involved 60 patients (39 males&21 females) diagnosed with hematological malignancies. Results: Of the sixty patients, seventeen patients (28.3 %) had IgM HGV positive, while 43 (71.7%) of patients had HGV IgM negative which was statistically significant when compared to control group. Conclusion: the incidence of HGV increase in patient with hematological malignancies receiving multiple blood transfusions.

Keywords

Incidence, Hepatitis G Virus, Hematological Malignancies, Blood Transfusion
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  • Zuckerman A (1996) Alphabet of hepatitis viruses. Lancet 1996, 347:558-9.

  • Roth W, Waschk D, Marx S, Tschauder S, Zeuzem S, Bialleck H, Weber H and Seifried E (1997) Prevalence of hepatitis G virus and itsstrain variant, the GB agent, in blood donations and theirtransmission to recipients. Transfusion. 37, 651-656

  • Linnen J, Wages J, Zhong-Keck Z-Y, et al. (1996) Molecular cloning and disease association of hepatitis G virus: a transfusion- transmissible agent. Sci. 271,505-508

  • Simmonds, P. 2000 Fleming Lecture. The origin and evolution of hepatitis viruses in humans. J. Gen. Virol. 2001; 82: 693-712

  • Robertson BH (2001) Viral hepatitis and primates: historical and molecular analysis of human and nonhuman primate hepatitis A, B, and the GB-related viruses. J.Viral Hepat. 8, 233-242

  • Idilam R, Ustun C, Aslan O, Ozcan M, Arat M, Bozkaya H, Sengezer T, Osden U, Dokmerci A, ilhan O,Koc H and Akan H . The incidence of hepatitis G virus in patients with hematological malignancies: the relationship to the number of blood and blood products transfusion.Turk. J. hematol.17,67-71

  • Cacopardo B, Berger A, Cosentino S, et al (1998) Serum hepatitis G virus RNA in multitransfused Thalassemics from Eastern Sicily. J.Infect. 36,179-183

  • Feucht HH, Fischer L, Sterneck M, Broelsch CE and Laufs R (1997) GB virus C transmission by blood products. Lancet .349, 435-436

  • Shibuya A, Takeuchi A, Kamata K, Saigenji K, Kobayashi N, Yoshida A (1998) Prevalence of hepatitis G virus RNA and anti-E2 in a Japanesehaemodialysis population. Nephrol Dial Transplant . 2033-2036

  • Schulte-Frohlinde E, Schmolke S, Reindl W, Schätzle G, Scherf J, Kopp K, Classen M and Schlüter V (1998) Significance of antibodies to recombinantE2 protein of hepatitis G virus in hemodialysispatients. J. Viral Hepat. 5, 341-344

  • Loiseau P, Mariotti M, Corbi C, et al. (1997) Prevalence of hepatitis G virus RNA in French blood donors and recipients. Transfusion. 37, 645-650

  • Heringlake S, Osterkamp S, Trautwein C, et al. (1996) Association between fulminant hepatic failure and a strain of GBV virus C. Lancet. 348,1626-1629

  • Linnen J, Wages J, Zhang-Keck ZY et al.(1996) Molecular cloning and disease association of hepatitis G virus: transfusiontransmissible agent. Sci. 271, 505-508

  • Skidmore SJ, Collingham KE, Harrison P, Neilson JR, Pillay D and Milligan DW (1997) High prevalence of hepatitis G virus in bone marrow transplant recipients and patients treated for acute leukemia. Blood. 89, 3853

  • Rodriguez IE, Tomas JF, Gomez GSV, Bartolome J, Pinilla I, Amaro MJ, Carreno V, and Fernandez RJ: Hepatitis C and G virus infection and liver dysfunction after allogeneic bone marrow transplantation: Results from a prospective study. Blood. 90,1326

  • Jarvis LM, Davidson F, Hanley JP, Yap PL, Ludlam CA and Simmonds P (1996) Infection with hepatitis G virus among recipients of plasma products. Lancet. 348,1352-1355

  • DE Renzo A, Persico E, DE Marino F, DI Giacomo GR, Notaro R,DI Grazia K, Picardi M, Santoro L, Torella R, Rotoli T, and Persico M (2002) High prevalence of hepatitis G virus infection in Hodgkin’s disease and B-cell lymphoproliferative disorders: absence of correlation with hepatitis C virus infection. Haematologica. 87,714-718

  • Ellenrieder V, Weidenbach H, Frickhofen N, Michel D, Prummer O, Klatt S, et al. (1998) HCV and HGV in B-cell non-Hodgkin’s lymphoma. J. Hepatol. 28,34-39

  • Zignego AL, Giannini C, Gentilini P, Bellesi G, Hadziyannis S and Ferri C (1997) Could HGV infection be implicated in lymphomagenesis? Br. J. Haematol. 98,778-779

  • Hammad AH and Zaghloul MH (2009) Hepatitis G virus infection in Egyptian children with chronic renal failure (single center study). Ann. Clin. Microbiol. Antimicrobials. 8,36


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  • Incidence of Hepatitis G Virus in Patients with Hematological Malignancies with Repeated Blood Transfusion

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Authors

Alaa Fadhil Alwan
Department of Clinical Hematology, The national center of Hematology, Almustansiriya University
Muhammad Marouf Alani
Department of Microbiology, University of Baghdad College of Medicine
Kifah Hamdan Abdulghafour
Department of Pathology, University of Baghdad College of Medicine

Abstract


Background: Hepatitis G virus and GB virus C (GBV-C) are RNA viruses that were independently identified in 1995, and were subsequently found to be two isolates of the same virus. Blood transfusion is the main risk factor for HGV transmission. Patients with hematological malignancies usually require frequent blood transfusions which make them more vulnerable to HGV infection. The aims of this study was to estimate the transmission rate of HGV in patients with hematological malignancies having multiple blood transfusion. Methods: This cross sectional study was carried out at the national center of hematology,Almustansiriya University and department of microbiology in Baghdad university college of medicine in Baghdad / Iraq from January till June 2012. The study involved 60 patients (39 males&21 females) diagnosed with hematological malignancies. Results: Of the sixty patients, seventeen patients (28.3 %) had IgM HGV positive, while 43 (71.7%) of patients had HGV IgM negative which was statistically significant when compared to control group. Conclusion: the incidence of HGV increase in patient with hematological malignancies receiving multiple blood transfusions.

Keywords


Incidence, Hepatitis G Virus, Hematological Malignancies, Blood Transfusion

References