Preparation and Evaluation of Vancomycin Polyelectrolyte Complex Nanoparticles

Background/Objectives: Nanoparticulate drug delivery has been a considerable research interest in the area of drug delivery using particulate delivery systems as carriers for bioactive agents. They show a promising approach to obtain desirable drug properties by altering the biopharmaceutical and pharmacokinetic properties of the molecule. Vancomycin is glycopeptide antibiotic with poor oral absorption. Methods/Statistical analysis: In the present research work vancomycin nanoparticles were prepared by polyelectrolyte Complexation technique using two pairs of oppositely charged natural polymers neem gum and chitosan as one pair and hupu gum and chitosan as another pair. The vancomycin nanoparticles were characterized by using Scanning electron microscopy (SEM), particle size distribution by Zeta sizer. The nanoparticles were evaluated for their efficiency in drug diffusion, in vitro antimicrobial activity. Results: Polyelectrolyte nanoparticles of vancomycin more effective when compared to pure drug. Conclusion/Application: Among all formulations, the formulation in which was the drug to polymer ratio 2:3 (in the case of neem gum Nanoparticulate suspension) and 1:2 (in case of hupu gum precipitate Nanoparticles) were found to be effective.