Impact of Kinship on the Chosen Autosomal Anomalies in Sivagangai, Tamil Nadu, India

Significance of Study: Prevalence of consanguinity and their impact on the autosomal recessive anomalies such as diabetes mellitus, hearing impairments, epilepsy, limb defect and eye defect among Sivagangai population was studied. The present investigation provides a new plat form for pinpointing out the genetic causes leading to congenital autosomal recessive disorder, so that in future newer gene therapy approaches can be developed to treat such anomalies. In our study, an attempt has been made to evaluate the association of the most common causes of autosomal recessive impairment among heterogeneous Sivagangai population.

Objective: To determine the effect of endogamy on the hereditary anomalies of Sivagangai population.

Study Design: Human health survey.

Method: The impacts of kinship against autosomal recessive disorder among the selected population of Sivagangai were studied. In this study, 2376 families were taken for assessment by face-to-face interviewed in the local language according to the standard procedures.

Result: Consanguineous marriage was significantly higher in current generations (29.62%) than the previous generations (37.94%). The occurrences of abnormality were higher among inter breeding populations (67.34%) than non consanguineous population (32.65%). The highest Odd ratio was recorded in epilepsy, followed by hearing impairment, limb defect and eye defects, while, the lowest value was observed in diabetic population. The highest P value, odd ratio and 95% Class Interval recorded were 0.001, 26.48 and 18.63-37.63 respectively. The highest degree of consanguinity reported in the study was 2^nd degree in epilepsy.

Conclusion: The present study showed that the hereditary anomalies were higher among cognate population than out breeding population. The children of such con sanguineous couples have higher risk of expressing recessive gene disorders.