Correlation of Interleukin-6 with Serum Estradiol Mean Levels in Menopause Women at Rsup H Adam Malik Medan

Aim: To determine the correlation of Interleukin-6 (IL-6) with serum estradiol levels in menopausal women.

Method: This research is a case series research in postmenopausal women to assess the correlation between Interleukin-6 (IL-6) and serum estradiol levels that performed at H Adam Malik General Hospital Medan, starting in August 2017 until 38 samples which met the inclusion and exclusion criteria were fulfill,using non probability sampling technique with consecutive sampling. Serum estradiol and IL-6 levels was examined, then sent to the clinical laboratory. Data tabulated to be analyzed statistically.

Results: The mean serum estradiol level in menopausal women is 29.74 ± 18.69. The mean IL-6 level was 85.03 ± 33.66, in this research showed that in menopausal women there was an increase in IL-6 levels. By using the Spearman Test, the results showed that there was a significant correlation between estradiol and IL-6 with p value <0.004.

Conclusion: There is a significant negative correlation between serum estradiol and IL-6 levels, which means that there is an inverse relationship between serum estradiol and IL-6 levels with weak negative strength, where decreasing estradiol does not always increase IL-6 levels.